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Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.

Publication ,  Journal Article
Jones, LW; Mourtzakis, M; Peters, KB; Friedman, AH; West, MJ; Mabe, SK; Kraus, WE; Friedman, HS; Reardon, DA
Published in: Oncologist
2010

PURPOSE: To investigate the feasibility of longitudinal assessment of functional performance measures in newly diagnosed postsurgical malignant glioma patients. METHODS: Patients with histologically confirmed, clinically stable, postsurgical, and previously untreated high-grade glioma (HGG) or low-grade glioma (LGG) were studied. Using a prospective design, all participants performed a cardiopulmonary exercise test with expired gas analysis to assess cardiorespiratory function (VO(2peak)) immediately following surgical resection (mean, 10 days). Additional functional outcomes were skeletal muscle cross-sectional area (CSA) via magnetic resonance imaging, isokinetic muscle strength (isokinetic dynamometry), and body composition (air displacement plethysmography). Quality of life (QOL) was assessed by the Functional Assessment of Cancer Therapy-Brain scale. All study assessments were repeated at 6 and 24 weeks following surgery. RESULTS: Thirty-five patients (HGG, n = 25; LGG, n = 10) completed baseline assessments. Of these, 20 HGG (80%) and nine LGG (90%) and 15 HGG (60%) and nine LGG (90%) patients completed study assessments at 6 weeks and 24 weeks, respectively. Intention-to-treat analyses indicated several significant time-by-group interactions, with favorable improvements in functional and QOL endpoints from baseline to 24 weeks in the LGG cohort and unfavorable changes in the HGG cohort. Per-protocol analyses including participants assessed at all three study timepoints indicated significant improvements in VO(2peak) and fatigue from baseline to 24 weeks in the HGG cohort; peak workload, body composition, and muscle strength improved from baseline to 6 weeks (all p-values < .05). CONCLUSIONS: Longitudinal quantitative functional assessments are safe and feasible among select patients undergoing chemoradiation for primary malignant glioma. Large prospective studies investigating the clinical importance of these measures appear warranted.

Duke Scholars

Published In

Oncologist

DOI

EISSN

1549-490X

Publication Date

2010

Volume

15

Issue

6

Start / End Page

636 / 647

Location

England

Related Subject Headings

  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Longitudinal Studies
  • Humans
  • Glioma
  • Feasibility Studies
  • Combined Modality Therapy
  • Brain Neoplasms
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jones, L. W., Mourtzakis, M., Peters, K. B., Friedman, A. H., West, M. J., Mabe, S. K., … Reardon, D. A. (2010). Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study. Oncologist, 15(6), 636–647. https://doi.org/10.1634/theoncologist.2009-0265
Jones, Lee W., Marina Mourtzakis, Katherine B. Peters, Allan H. Friedman, Miranda J. West, Stephanie K. Mabe, William E. Kraus, Henry S. Friedman, and David A. Reardon. “Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.Oncologist 15, no. 6 (2010): 636–47. https://doi.org/10.1634/theoncologist.2009-0265.
Jones LW, Mourtzakis M, Peters KB, Friedman AH, West MJ, Mabe SK, et al. Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study. Oncologist. 2010;15(6):636–47.
Jones, Lee W., et al. “Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.Oncologist, vol. 15, no. 6, 2010, pp. 636–47. Pubmed, doi:10.1634/theoncologist.2009-0265.
Jones LW, Mourtzakis M, Peters KB, Friedman AH, West MJ, Mabe SK, Kraus WE, Friedman HS, Reardon DA. Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study. Oncologist. 2010;15(6):636–647.

Published In

Oncologist

DOI

EISSN

1549-490X

Publication Date

2010

Volume

15

Issue

6

Start / End Page

636 / 647

Location

England

Related Subject Headings

  • Quality of Life
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Longitudinal Studies
  • Humans
  • Glioma
  • Feasibility Studies
  • Combined Modality Therapy
  • Brain Neoplasms
  • Adult