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Early breast cancer therapy and cardiovascular injury.

Publication ,  Journal Article
Jones, LW; Haykowsky, MJ; Swartz, JJ; Douglas, PS; Mackey, JR
Published in: J Am Coll Cardiol
October 9, 2007

Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy and proposes a new entity that we have labeled the "multiple-hit" hypothesis. The evidence that lifestyle modification, especially exercise therapy, may mitigate these adverse effects is also reviewed. These issues are of considerable practical importance for cardiovascular clinicians, as identification and intervention in those at high risk for cardiovascular complications may reduce a major cause of mortality in women with early breast cancer.

Duke Scholars

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

October 9, 2007

Volume

50

Issue

15

Start / End Page

1435 / 1441

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Risk Factors
  • Risk Assessment
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Radiotherapy, Adjuvant
  • Overweight
  • Obesity
  • Neovascularization, Pathologic
 

Citation

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Jones, L. W., Haykowsky, M. J., Swartz, J. J., Douglas, P. S., & Mackey, J. R. (2007). Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol, 50(15), 1435–1441. https://doi.org/10.1016/j.jacc.2007.06.037
Jones, Lee W., Mark J. Haykowsky, Jonas J. Swartz, Pamela S. Douglas, and John R. Mackey. “Early breast cancer therapy and cardiovascular injury.J Am Coll Cardiol 50, no. 15 (October 9, 2007): 1435–41. https://doi.org/10.1016/j.jacc.2007.06.037.
Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol. 2007 Oct 9;50(15):1435–41.
Jones, Lee W., et al. “Early breast cancer therapy and cardiovascular injury.J Am Coll Cardiol, vol. 50, no. 15, Oct. 2007, pp. 1435–41. Pubmed, doi:10.1016/j.jacc.2007.06.037.
Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol. 2007 Oct 9;50(15):1435–1441.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

October 9, 2007

Volume

50

Issue

15

Start / End Page

1435 / 1441

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Risk Factors
  • Risk Assessment
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Radiotherapy, Adjuvant
  • Overweight
  • Obesity
  • Neovascularization, Pathologic