Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts.
Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients undergoing adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents.Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n = 21 per group): (a) control, (b) exercise-only, (c) doxorubicin-only, or (d) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18 m/min at 0% grade for 45 minutes, 5 d/wk for 8 weeks.Tumor growth delay was significantly longer in the doxorubicin-only and exercise + doxorubicin groups compared with the control (median 42 versus 25 days, P = 0.0082; 36 versus 25 days, P = 0.029, respectively) and exercise-only groups (median 42 versus 25 days, P = 0.029; 36 versus 25 days, P = 0.080, respectively). There was no significant difference between the doxorubicin-only and exercise + doxorubicin groups (median 42 versus 36 days, P = 0.33), suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay.These studies are essential to fully understand the safety and application of exercise as a supportive intervention in cancer control.
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Related Subject Headings
- Xenograft Model Antitumor Assays
- Time Factors
- Survival Analysis
- Random Allocation
- Physical Conditioning, Animal
- Oncology & Carcinogenesis
- Mice, Nude
- Mice
- Mammary Neoplasms, Experimental
- Humans
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Xenograft Model Antitumor Assays
- Time Factors
- Survival Analysis
- Random Allocation
- Physical Conditioning, Animal
- Oncology & Carcinogenesis
- Mice, Nude
- Mice
- Mammary Neoplasms, Experimental
- Humans