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Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.

Publication ,  Journal Article
Jones, LW; Friedman, AH; West, MJ; Mabe, SK; Fraser, J; Kraus, WE; Friedman, HS; Tresch, MI; Major, N; Reardon, DA
Published in: Cancer
February 1, 2010

BACKGROUND: The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma. METHODS: By using a cross-sectional design, patients with clinically stable (10 +/- 7 days postsurgery) high-grade glioma (HGG; n = 25) or low-grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross-sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy-Brain scale. RESULTS: CPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL x weight x min(-1) and 19 mL x LBM x min(-1), the equivalent to 59% and 38% below age- and sex-predicted normative values, respectively. Skeletal muscle strength and mid-thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = -0.59 to 0.68, P < .05). CONCLUSIONS: Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

February 1, 2010

Volume

116

Issue

3

Start / End Page

695 / 704

Location

United States

Related Subject Headings

  • Respiration
  • Quality of Life
  • Physical Fitness
  • Oxygen Consumption
  • Oncology & Carcinogenesis
  • Muscle, Skeletal
  • Muscle Strength
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Jones, L. W., Friedman, A. H., West, M. J., Mabe, S. K., Fraser, J., Kraus, W. E., … Reardon, D. A. (2010). Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. Cancer, 116(3), 695–704. https://doi.org/10.1002/cncr.24808
Jones, Lee W., Allan H. Friedman, Miranda J. West, Stephanie K. Mabe, Jennifer Fraser, William E. Kraus, Henry S. Friedman, Maura I. Tresch, Nancy Major, and David A. Reardon. “Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.Cancer 116, no. 3 (February 1, 2010): 695–704. https://doi.org/10.1002/cncr.24808.
Jones LW, Friedman AH, West MJ, Mabe SK, Fraser J, Kraus WE, et al. Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. Cancer. 2010 Feb 1;116(3):695–704.
Jones, Lee W., et al. “Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.Cancer, vol. 116, no. 3, Feb. 2010, pp. 695–704. Pubmed, doi:10.1002/cncr.24808.
Jones LW, Friedman AH, West MJ, Mabe SK, Fraser J, Kraus WE, Friedman HS, Tresch MI, Major N, Reardon DA. Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma. Cancer. 2010 Feb 1;116(3):695–704.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

February 1, 2010

Volume

116

Issue

3

Start / End Page

695 / 704

Location

United States

Related Subject Headings

  • Respiration
  • Quality of Life
  • Physical Fitness
  • Oxygen Consumption
  • Oncology & Carcinogenesis
  • Muscle, Skeletal
  • Muscle Strength
  • Middle Aged
  • Male
  • Humans