Skip to main content
Journal cover image

Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis.

Publication ,  Journal Article
Cai, J; Read, PW; Larner, JM; Jones, DR; Benedict, SH; Sheng, K
Published in: Int J Radiat Oncol Biol Phys
November 15, 2008

PURPOSE: To investigate the statistical reproducibility of craniocaudal probability distribution function (PDF) of interfraction lung motion using dynamic magnetic resonance imaging. METHODS AND MATERIALS: A total of 17 subjects, 9 healthy volunteers and 8 lung tumor patients, underwent two to three continuous 300-s magnetic resonance imaging scans in the sagittal plane, repeated 2 weeks apart. Three pulmonary vessels from different lung regions (upper, middle, and lower) in the healthy subjects and lung tumor patients were selected for tracking, and the displacement PDF reproducibility was evaluated as a function of scan time and frame rate. RESULTS: For both healthy subjects and patients, the PDF reproducibility improved with increased scan time and converged to an equilibrium state during the 300-s scan. The PDF reproducibility at 300 s (mean, 0.86; range, 0.70-0.96) were significantly (p < 0.001) increased compared with those at 5 s (mean, 0.65; range, 0.25-0.79). PDF reproducibility showed less sensitivity to imaging frame rates that were >2 frames/s. CONCLUSION: A statistically significant improvement in PDF reproducibility was observed with a prolonged scan time among the 17 participants. The confirmation of PDF reproducibility over times much shorter than stereotactic body radiotherapy delivery duration is a vital part of the initial validation process of probability-based treatment planning for stereotactic body radiotherapy for lung cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2008

Volume

72

Issue

4

Start / End Page

1228 / 1235

Location

United States

Related Subject Headings

  • Statistical Distributions
  • Sensitivity and Specificity
  • Respiratory Mechanics
  • Reproducibility of Results
  • Radiotherapy, Computer-Assisted
  • Radiotherapy Planning, Computer-Assisted
  • Oncology & Carcinogenesis
  • Motion
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cai, J., Read, P. W., Larner, J. M., Jones, D. R., Benedict, S. H., & Sheng, K. (2008). Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis. Int J Radiat Oncol Biol Phys, 72(4), 1228–1235. https://doi.org/10.1016/j.ijrobp.2008.07.028
Cai, Jing, Paul W. Read, James M. Larner, David R. Jones, Stanley H. Benedict, and Ke Sheng. “Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis.Int J Radiat Oncol Biol Phys 72, no. 4 (November 15, 2008): 1228–35. https://doi.org/10.1016/j.ijrobp.2008.07.028.
Cai J, Read PW, Larner JM, Jones DR, Benedict SH, Sheng K. Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis. Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1228–35.
Cai, Jing, et al. “Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis.Int J Radiat Oncol Biol Phys, vol. 72, no. 4, Nov. 2008, pp. 1228–35. Pubmed, doi:10.1016/j.ijrobp.2008.07.028.
Cai J, Read PW, Larner JM, Jones DR, Benedict SH, Sheng K. Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis. Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1228–1235.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2008

Volume

72

Issue

4

Start / End Page

1228 / 1235

Location

United States

Related Subject Headings

  • Statistical Distributions
  • Sensitivity and Specificity
  • Respiratory Mechanics
  • Reproducibility of Results
  • Radiotherapy, Computer-Assisted
  • Radiotherapy Planning, Computer-Assisted
  • Oncology & Carcinogenesis
  • Motion
  • Middle Aged
  • Male