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Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects.

Publication ,  Journal Article
Bogden, JD; Oleske, JM; Munves, EM; Lavenhar, MA; Bruening, KS; Kemp, FW; Holding, KJ; Denny, TN; Louria, DB
Published in: Am J Clin Nutr
July 1987

Zinc nutriture and immune function were studied in 100 subjects, age 60-89 yr. Mean (+/- SD) zinc concentrations found were 84.8 +/- 15.5 micrograms/dL (13.0 +/- 2.4 microM) for plasma, 1.04 +/- 0.24 micrograms (0.016 +/- 0.004 mumol)/10(9) cells for erythrocytes, 4.06 +/- 1.85 micrograms (0.062 +/- 0.028 mumol)/10(9) cells for mononuclear cells, 3.91 +/- 1.77 micrograms (0.060 +/- 0.027 mumol)/10(9) cells for polymorphonuclear leukocytes, 0.53 +/- 0.39 micrograms (0.0081 +/- 0.0060 mumol)/10(9) cells for platelets, and 222 +/- 101 micrograms (3.39 +/- 1.54 mumol)/g for hair. Zinc ingestion was below the RDA in more than 90% of study subjects. The incidence of anergy to a panel of seven skin test antigens was 41%; responses to these antigens were significantly associated with the plasma zinc concentration. Subjects with depressed lymphocyte responses to mitogens had significantly lower platelet and significantly higher mononuclear cell zinc concentrations than those with normal responses.

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Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

July 1987

Volume

46

Issue

1

Start / End Page

101 / 109

Location

United States

Related Subject Headings

  • Zinc
  • Nutritional Requirements
  • Nutrition & Dietetics
  • Neutrophils
  • Monocytes
  • Male
  • Immunocompetence
  • Humans
  • Hair
  • Female
 

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Bogden, J. D., Oleske, J. M., Munves, E. M., Lavenhar, M. A., Bruening, K. S., Kemp, F. W., … Louria, D. B. (1987). Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr, 46(1), 101–109. https://doi.org/10.1093/ajcn/46.1.101
Bogden, J. D., J. M. Oleske, E. M. Munves, M. A. Lavenhar, K. S. Bruening, F. W. Kemp, K. J. Holding, T. N. Denny, and D. B. Louria. “Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects.Am J Clin Nutr 46, no. 1 (July 1987): 101–9. https://doi.org/10.1093/ajcn/46.1.101.
Bogden JD, Oleske JM, Munves EM, Lavenhar MA, Bruening KS, Kemp FW, et al. Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr. 1987 Jul;46(1):101–9.
Bogden, J. D., et al. “Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects.Am J Clin Nutr, vol. 46, no. 1, July 1987, pp. 101–09. Pubmed, doi:10.1093/ajcn/46.1.101.
Bogden JD, Oleske JM, Munves EM, Lavenhar MA, Bruening KS, Kemp FW, Holding KJ, Denny TN, Louria DB. Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr. 1987 Jul;46(1):101–109.

Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

July 1987

Volume

46

Issue

1

Start / End Page

101 / 109

Location

United States

Related Subject Headings

  • Zinc
  • Nutritional Requirements
  • Nutrition & Dietetics
  • Neutrophils
  • Monocytes
  • Male
  • Immunocompetence
  • Humans
  • Hair
  • Female