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Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.

Publication ,  Journal Article
Kersey, FR; Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL
Published in: ACS Nano
September 28, 2010

Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. The incorporation of luminescent molecules into NPs adds optical imaging and sensing capability to these vectors. Here we report on the synthesis of dual-emissive, pegylated NPs with "stealth"-like properties, delivered intravenously (IV), for the study of tumor accumulation. The NPs were created by means of stereocomplexation using a methoxy-terminated polyethylene glycol and poly(D-lactide) (mPEG-PDLA) block copolymer combined with iodide-substituted difluoroboron dibenzoylmethane-poly(L-lactide) (BF2dbm(I)PLLA). Boron nanoparticles (BNPs) were fabricated in two different solvent compositions to study the effects on BNP size distribution. The physical and photoluminescent properties of the BNPs were studied in vitro over time to determine stability. Finally, preliminary in vivo results show that stereocomplexed BNPs injected IV are taken up by tumors, an important prerequisite to their use as hypoxia imaging agents in preclinical studies.

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Published In

ACS Nano

DOI

EISSN

1936-086X

Publication Date

September 28, 2010

Volume

4

Issue

9

Start / End Page

4989 / 4996

Location

United States

Related Subject Headings

  • Stereoisomerism
  • Spectrum Analysis
  • Solvents
  • Polymers
  • Polyethylene Glycols
  • Polyesters
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Nanomedicine
  • Molecular Imaging
 

Citation

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Kersey, F. R., Zhang, G., Palmer, G. M., Dewhirst, M. W., & Fraser, C. L. (2010). Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. ACS Nano, 4(9), 4989–4996. https://doi.org/10.1021/nn901873t
Kersey, Farrell R., Guoqing Zhang, Gregory M. Palmer, Mark W. Dewhirst, and Cassandra L. Fraser. “Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.ACS Nano 4, no. 9 (September 28, 2010): 4989–96. https://doi.org/10.1021/nn901873t.
Kersey FR, Zhang G, Palmer GM, Dewhirst MW, Fraser CL. Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. ACS Nano. 2010 Sep 28;4(9):4989–96.
Kersey, Farrell R., et al. “Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.ACS Nano, vol. 4, no. 9, Sept. 2010, pp. 4989–96. Pubmed, doi:10.1021/nn901873t.
Kersey FR, Zhang G, Palmer GM, Dewhirst MW, Fraser CL. Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. ACS Nano. 2010 Sep 28;4(9):4989–4996.
Journal cover image

Published In

ACS Nano

DOI

EISSN

1936-086X

Publication Date

September 28, 2010

Volume

4

Issue

9

Start / End Page

4989 / 4996

Location

United States

Related Subject Headings

  • Stereoisomerism
  • Spectrum Analysis
  • Solvents
  • Polymers
  • Polyethylene Glycols
  • Polyesters
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Nanomedicine
  • Molecular Imaging