Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.
Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.
Duke Scholars
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- Treatment Outcome
- Prognosis
- Physical Conditioning, Animal
- Neurology & Neurosurgery
- Neoplasms
- Mice
- Humans
- Exercise Therapy
- Disease Progression
- Animals
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Prognosis
- Physical Conditioning, Animal
- Neurology & Neurosurgery
- Neoplasms
- Mice
- Humans
- Exercise Therapy
- Disease Progression
- Animals