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Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

Publication ,  Journal Article
Betof, AS; Dewhirst, MW; Jones, LW
Published in: Brain Behav Immun
March 2013

Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.

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Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

March 2013

Volume

30 Suppl

Issue

0

Start / End Page

S75 / S87

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Physical Conditioning, Animal
  • Neurology & Neurosurgery
  • Neoplasms
  • Mice
  • Humans
  • Exercise Therapy
  • Disease Progression
  • Animals
 

Citation

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Betof, A. S., Dewhirst, M. W., & Jones, L. W. (2013). Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun, 30 Suppl(0), S75–S87. https://doi.org/10.1016/j.bbi.2012.05.001
Betof, Allison S., Mark W. Dewhirst, and Lee W. Jones. “Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.Brain Behav Immun 30 Suppl, no. 0 (March 2013): S75–87. https://doi.org/10.1016/j.bbi.2012.05.001.
Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun. 2013 Mar;30 Suppl(0):S75–87.
Betof, Allison S., et al. “Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.Brain Behav Immun, vol. 30 Suppl, no. 0, Mar. 2013, pp. S75–87. Pubmed, doi:10.1016/j.bbi.2012.05.001.
Betof AS, Dewhirst MW, Jones LW. Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain Behav Immun. 2013 Mar;30 Suppl(0):S75–S87.
Journal cover image

Published In

Brain Behav Immun

DOI

EISSN

1090-2139

Publication Date

March 2013

Volume

30 Suppl

Issue

0

Start / End Page

S75 / S87

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Physical Conditioning, Animal
  • Neurology & Neurosurgery
  • Neoplasms
  • Mice
  • Humans
  • Exercise Therapy
  • Disease Progression
  • Animals