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Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.

Publication ,  Journal Article
Wetsel, WC; Fernstrom, JD
Published in: Brain Res
April 9, 1986

The in vivo incorporation of [35S]cysteine into hypothalamic somatostatin-28 was found to be substantially below normal in hypophysectomized rats. A smaller reduction in label incorporation into arginine vasopressin was also observed, while incorporation into acid-precipitable protein was normal. The diminution in somatostatin biosynthesis presumably reflects the absence of pituitary growth hormone secretion, while that in vasopressin synthesis may reflect the loss or disruption of vasopressin-producing cells.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

April 9, 1986

Volume

370

Issue

2

Start / End Page

315 / 320

Location

Netherlands

Related Subject Headings

  • Sulfur Radioisotopes
  • Somatostatin-28
  • Somatostatin
  • Rats, Inbred Strains
  • Rats
  • Protein Precursors
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Male
  • Kinetics
 

Citation

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Wetsel, W. C., & Fernstrom, J. D. (1986). Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus. Brain Res, 370(2), 315–320. https://doi.org/10.1016/0006-8993(86)90486-5
Wetsel, W. C., and J. D. Fernstrom. “Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.Brain Res 370, no. 2 (April 9, 1986): 315–20. https://doi.org/10.1016/0006-8993(86)90486-5.
Wetsel, W. C., and J. D. Fernstrom. “Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.Brain Res, vol. 370, no. 2, Apr. 1986, pp. 315–20. Pubmed, doi:10.1016/0006-8993(86)90486-5.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

April 9, 1986

Volume

370

Issue

2

Start / End Page

315 / 320

Location

Netherlands

Related Subject Headings

  • Sulfur Radioisotopes
  • Somatostatin-28
  • Somatostatin
  • Rats, Inbred Strains
  • Rats
  • Protein Precursors
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Male
  • Kinetics