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Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.

Publication ,  Journal Article
Bousquet-Moore, D; Prohaska, JR; Nillni, EA; Czyzyk, T; Wetsel, WC; Mains, RE; Eipper, BA
Published in: Neurobiol Dis
January 2010

Mammalian genomes encode only a small number of cuproenzymes. The many genes involved in coordinating copper uptake, distribution, storage and efflux make gene/nutrient interactions especially important for these cuproenzymes. Copper deficiency and copper excess both disrupt neural function. Using mice heterozygous for peptidylglycine alpha-amidating monooxygenase (PAM), a cuproenzyme essential for the synthesis of many neuropeptides, we identified alterations in anxiety-like behavior, thermoregulation and seizure sensitivity. Dietary copper supplementation reversed a subset of these deficits. Wildtype mice maintained on a marginally copper-deficient diet exhibited some of the same deficits observed in PAM(+/-) mice and displayed alterations in PAM metabolism. Altered copper homeostasis in PAM(+/-) mice suggested a role for PAM in the cell type specific regulation of copper metabolism. Physiological functions sensitive to genetic limitations of PAM that are reversed by supplemental copper and mimicked by copper deficiency may serve as indicators of marginal copper deficiency.

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Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

January 2010

Volume

37

Issue

1

Start / End Page

130 / 140

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Seizures
  • Peptides
  • Pentylenetetrazole
  • Neurology & Neurosurgery
  • Multienzyme Complexes
  • Mixed Function Oxygenases
  • Mice, Transgenic
  • Mice
  • Male
 

Citation

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Chicago
ICMJE
MLA
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Bousquet-Moore, D., Prohaska, J. R., Nillni, E. A., Czyzyk, T., Wetsel, W. C., Mains, R. E., & Eipper, B. A. (2010). Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis, 37(1), 130–140. https://doi.org/10.1016/j.nbd.2009.09.016
Bousquet-Moore, Danielle, Joseph R. Prohaska, Eduardo A. Nillni, Traci Czyzyk, William C. Wetsel, Richard E. Mains, and Betty A. Eipper. “Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.Neurobiol Dis 37, no. 1 (January 2010): 130–40. https://doi.org/10.1016/j.nbd.2009.09.016.
Bousquet-Moore D, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, et al. Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis. 2010 Jan;37(1):130–40.
Bousquet-Moore, Danielle, et al. “Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.Neurobiol Dis, vol. 37, no. 1, Jan. 2010, pp. 130–40. Pubmed, doi:10.1016/j.nbd.2009.09.016.
Bousquet-Moore D, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA. Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis. 2010 Jan;37(1):130–140.
Journal cover image

Published In

Neurobiol Dis

DOI

EISSN

1095-953X

Publication Date

January 2010

Volume

37

Issue

1

Start / End Page

130 / 140

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Seizures
  • Peptides
  • Pentylenetetrazole
  • Neurology & Neurosurgery
  • Multienzyme Complexes
  • Mixed Function Oxygenases
  • Mice, Transgenic
  • Mice
  • Male