Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia.
Publication
, Journal Article
Porton, B; Wetsel, WC
Published in: Schizophr Res
August 2007
We analyzed the expression of a presynaptic protein, synapsin III, in individuals with schizophrenia. Since levels of synapsin III were previously found to be significantly reduced in the hippocampus of individuals with schizophrenia, we examined another brain region believed to be a major locus of dysfunction in schizophrenia, the dorsolateral prefrontal cortex (DLPFC). Western blot analyses using tissue obtained from the Stanley Foundation Neuropathology Consortium revealed that synapsin III levels were significantly decreased in the DLPFC of individuals with schizophrenia compared to controls. These findings are consistent with growing evidence of presynaptic abnormalities and prefrontal cortical dysfunction in schizophrenia.
Duke Scholars
Published In
Schizophr Res
DOI
ISSN
0920-9964
Publication Date
August 2007
Volume
94
Issue
1-3
Start / End Page
366 / 370
Location
Netherlands
Related Subject Headings
- Synapsins
- Schizophrenia
- Receptors, Presynaptic
- Psychiatry
- Prefrontal Cortex
- Male
- Humans
- Female
- Diagnostic and Statistical Manual of Mental Disorders
- Blotting, Western
Citation
APA
Chicago
ICMJE
MLA
NLM
Porton, B., & Wetsel, W. C. (2007). Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia. Schizophr Res, 94(1–3), 366–370. https://doi.org/10.1016/j.schres.2007.04.016
Porton, Barbara, and William C. Wetsel. “Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia.” Schizophr Res 94, no. 1–3 (August 2007): 366–70. https://doi.org/10.1016/j.schres.2007.04.016.
Porton B, Wetsel WC. Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia. Schizophr Res. 2007 Aug;94(1–3):366–70.
Porton, Barbara, and William C. Wetsel. “Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia.” Schizophr Res, vol. 94, no. 1–3, Aug. 2007, pp. 366–70. Pubmed, doi:10.1016/j.schres.2007.04.016.
Porton B, Wetsel WC. Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia. Schizophr Res. 2007 Aug;94(1–3):366–370.
Published In
Schizophr Res
DOI
ISSN
0920-9964
Publication Date
August 2007
Volume
94
Issue
1-3
Start / End Page
366 / 370
Location
Netherlands
Related Subject Headings
- Synapsins
- Schizophrenia
- Receptors, Presynaptic
- Psychiatry
- Prefrontal Cortex
- Male
- Humans
- Female
- Diagnostic and Statistical Manual of Mental Disorders
- Blotting, Western