Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli.
Publication
, Journal Article
Wilson, KH; Sheagren, JN; Freter, R; Weatherbee, L; Lyerly, D
Published in: J Infect Dis
March 1986
Hamster flora introduced into germfree mice reduced the cecum to conventional size, suppressed populations of Escherichia coli and Clostridium difficile to the same degree that mouse flora did, and corrected the hypocellularity that is characteristic of the small bowel of germfree mice. A highly toxigenic strain of C. difficile readily induced cecitis in germfree and antibiotic-treated conventional mice, and histological examination frequently revealed pseudomembranes. Toxins A and B were both detected in ceca of animals with colitis. Gnotobiotic mice provide a model in which to study the role of the indigenous microflora in protecting against antibiotic-associated colitis.
Duke Scholars
Published In
J Infect Dis
DOI
ISSN
0022-1899
Publication Date
March 1986
Volume
153
Issue
3
Start / End Page
547 / 551
Location
United States
Related Subject Headings
- Microbiology
- Mice
- Mesocricetus
- Male
- Germ-Free Life
- Escherichia coli
- Enzyme-Linked Immunosorbent Assay
- Cricetinae
- Colitis
- Clostridium
Citation
APA
Chicago
ICMJE
MLA
NLM
Wilson, K. H., Sheagren, J. N., Freter, R., Weatherbee, L., & Lyerly, D. (1986). Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. J Infect Dis, 153(3), 547–551. https://doi.org/10.1093/infdis/153.3.547
Wilson, K. H., J. N. Sheagren, R. Freter, L. Weatherbee, and D. Lyerly. “Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli.” J Infect Dis 153, no. 3 (March 1986): 547–51. https://doi.org/10.1093/infdis/153.3.547.
Wilson KH, Sheagren JN, Freter R, Weatherbee L, Lyerly D. Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. J Infect Dis. 1986 Mar;153(3):547–51.
Wilson, K. H., et al. “Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli.” J Infect Dis, vol. 153, no. 3, Mar. 1986, pp. 547–51. Pubmed, doi:10.1093/infdis/153.3.547.
Wilson KH, Sheagren JN, Freter R, Weatherbee L, Lyerly D. Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. J Infect Dis. 1986 Mar;153(3):547–551.
Published In
J Infect Dis
DOI
ISSN
0022-1899
Publication Date
March 1986
Volume
153
Issue
3
Start / End Page
547 / 551
Location
United States
Related Subject Headings
- Microbiology
- Mice
- Mesocricetus
- Male
- Germ-Free Life
- Escherichia coli
- Enzyme-Linked Immunosorbent Assay
- Cricetinae
- Colitis
- Clostridium