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Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

Publication ,  Journal Article
Rath, HC; Herfarth, HH; Ikeda, JS; Grenther, WB; Hamm, TE; Balish, E; Taurog, JD; Hammer, RE; Wilson, KH; Sartor, RB
Published in: J Clin Invest
August 15, 1996

Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal luminal bacteria and several groups of selected bacterial strains on spontaneous gastrointestinal and systemic inflammation in HLA-B27 transgenic rats. Rats maintained germfree for 3-9 mo were compared with littermates conventionalized with specific pathogen-free bacteria. Subsequently, germfree transgenic rats were colonized with groups of five to eight bacteria that were either facultative or strictly anaerobic. Transgenic germfree rats had no gastroduodenitis, colitis, or arthritis, but developed epididymitis and dermatitis to the same degree as conventionalized rats. Colonic proinflammatory cytokine expression was increased in transgenic conventionalized rats but was undetectable in germfree and nontransgenic rats. Colitis progressively increased over the first 4 wk of bacterial exposure, then plateaued. Only transgenic rats colonized with defined bacterial cocktails which contained Bacteroides spp. had colitis and gastritis. Normal luminal bacteria predictably and uniformly induce chronic colonic, gastric and systemic inflammation in B27 transgenic F344 rats, but all bacterial species do not have equal activities.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

August 15, 1996

Volume

98

Issue

4

Start / End Page

945 / 953

Location

United States

Related Subject Headings

  • beta 2-Microglobulin
  • Rats
  • RNA, Messenger
  • Molecular Sequence Data
  • Immunology
  • Humans
  • HLA-B27 Antigen
  • Gene Expression
  • Gastritis
  • Digestive System
 

Citation

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Rath, H. C., Herfarth, H. H., Ikeda, J. S., Grenther, W. B., Hamm, T. E., Balish, E., … Sartor, R. B. (1996). Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest, 98(4), 945–953. https://doi.org/10.1172/JCI118878
Rath, H. C., H. H. Herfarth, J. S. Ikeda, W. B. Grenther, T. E. Hamm, E. Balish, J. D. Taurog, R. E. Hammer, K. H. Wilson, and R. B. Sartor. “Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.J Clin Invest 98, no. 4 (August 15, 1996): 945–53. https://doi.org/10.1172/JCI118878.
Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Balish E, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996 Aug 15;98(4):945–53.
Rath, H. C., et al. “Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.J Clin Invest, vol. 98, no. 4, Aug. 1996, pp. 945–53. Pubmed, doi:10.1172/JCI118878.
Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996 Aug 15;98(4):945–953.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

August 15, 1996

Volume

98

Issue

4

Start / End Page

945 / 953

Location

United States

Related Subject Headings

  • beta 2-Microglobulin
  • Rats
  • RNA, Messenger
  • Molecular Sequence Data
  • Immunology
  • Humans
  • HLA-B27 Antigen
  • Gene Expression
  • Gastritis
  • Digestive System