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Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy.

Publication ,  Journal Article
Lauersen, NH; Wilson, KH
Published in: Am J Obstet Gynecol
February 15, 1976

Pregnancy was successfully terminated in 8 of 9 patients 5 to 6 weeks after the last menstrual period by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha (15-ME-PGF2alpha). In one patient the treatment induced vaginal bleeding and a drop in hormone levels, but the patient did not completely abort and the uterus had to be evacuated. Serial intramuscular injections of 15-ME-PGF2alpha appeared to have some luteolytic effect, resulting in a significant drop in progesterone and estradiol levels. However, it is uncertain if the luteolytic effect of the prostaglandin was the precipitating factor in the abortion since the administration of 15-ME-PFG2alpha was accompanied by strong uterine activity which played a role in the abortion.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

February 15, 1976

Volume

124

Issue

4

Start / End Page

425 / 429

Location

United States

Related Subject Headings

  • Uterine Contraction
  • Prostaglandins F
  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy
  • Placental Lactogen
  • Obstetrics & Reproductive Medicine
  • Luteolytic Agents
  • Injections, Intramuscular
  • Humans
 

Citation

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MLA
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Lauersen, N. H., & Wilson, K. H. (1976). Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy. Am J Obstet Gynecol, 124(4), 425–429. https://doi.org/10.1016/0002-9378(76)90106-x
Lauersen, N. H., and K. H. Wilson. “Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy.Am J Obstet Gynecol 124, no. 4 (February 15, 1976): 425–29. https://doi.org/10.1016/0002-9378(76)90106-x.
Lauersen, N. H., and K. H. Wilson. “Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy.Am J Obstet Gynecol, vol. 124, no. 4, Feb. 1976, pp. 425–29. Pubmed, doi:10.1016/0002-9378(76)90106-x.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

February 15, 1976

Volume

124

Issue

4

Start / End Page

425 / 429

Location

United States

Related Subject Headings

  • Uterine Contraction
  • Prostaglandins F
  • Progesterone
  • Pregnancy Trimester, First
  • Pregnancy
  • Placental Lactogen
  • Obstetrics & Reproductive Medicine
  • Luteolytic Agents
  • Injections, Intramuscular
  • Humans