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Image-guided radiosurgery of head and neck cancers.

Publication ,  Journal Article
Ryu, S; Khan, M; Yin, F-F; Concus, A; Ajlouni, M; Benninger, MS; Kim, JH
Published in: Otolaryngol Head Neck Surg
June 2004

OBJECTIVES: Radiosurgery precisely delivers a single high dose or a few fractionated doses of radiation to a localized tumor via the stereotactic approach. Some head and neck sites are suitable for radiosurgery since there is minimal or no organ motion. The clinical studies were carried out to determine the accuracy of stereotactic radiosurgery and to demonstrate the effectiveness of radiosurgery in head and neck cancers. MATERIALS AND METHODS: Thirteen patients were treated with either single-dose or fractionated radiosurgery to the tumor. All patients except one with cancer of the lip had received prior treatments including surgery, radiotherapy, and chemotherapy for the primary cancers. The dose ranged 12 to 18 Gy for single-dose radiosurgery and 30 Gy in 5 or 6 fractions twice a week for fractionated radiosurgery. Tumor localization was achieved via the stereotactic approach. RESULTS: Accuracy of radiosurgery was within 1.5 mm. Despite the recurrent disease from previous heavy treatments, 9 patients (70%) showed a significant response (complete or >50% tumor reduction) to radiosurgery, and 3 patients had stable disease. Complete tumor response was achieved in 6 patients. All patients had excellent pain relief with functional and cosmetic preservation. There was no acute and subacute radiation toxicity detected clinically during the minimal follow-up of 6 months. CONCLUSION: Image-guided radiosurgery is effective in achieving the local tumor control and pain relief. Radiosurgery provided excellent functional and cosmetic preservation with minimal complication. The results indicate the potential of radiosurgery in the treatment of recurrent and selected primary head and neck cancers.

Duke Scholars

Published In

Otolaryngol Head Neck Surg

DOI

ISSN

0194-5998

Publication Date

June 2004

Volume

130

Issue

6

Start / End Page

690 / 697

Location

England

Related Subject Headings

  • Surgery, Computer-Assisted
  • Stereotaxic Techniques
  • Radiosurgery
  • Otorhinolaryngology
  • Humans
  • Head and Neck Neoplasms
  • Follow-Up Studies
  • Dose Fractionation, Radiation
  • Combined Modality Therapy
  • Carcinoma, Squamous Cell
 

Citation

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MLA
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Ryu, S., Khan, M., Yin, F.-F., Concus, A., Ajlouni, M., Benninger, M. S., & Kim, J. H. (2004). Image-guided radiosurgery of head and neck cancers. Otolaryngol Head Neck Surg, 130(6), 690–697. https://doi.org/10.1016/j.otohns.2003.10.009
Ryu, Samuel, Mumtaz Khan, Fang-Fang Yin, Adrianne Concus, Munther Ajlouni, Michael S. Benninger, and Jae Ho Kim. “Image-guided radiosurgery of head and neck cancers.Otolaryngol Head Neck Surg 130, no. 6 (June 2004): 690–97. https://doi.org/10.1016/j.otohns.2003.10.009.
Ryu S, Khan M, Yin F-F, Concus A, Ajlouni M, Benninger MS, et al. Image-guided radiosurgery of head and neck cancers. Otolaryngol Head Neck Surg. 2004 Jun;130(6):690–7.
Ryu, Samuel, et al. “Image-guided radiosurgery of head and neck cancers.Otolaryngol Head Neck Surg, vol. 130, no. 6, June 2004, pp. 690–97. Pubmed, doi:10.1016/j.otohns.2003.10.009.
Ryu S, Khan M, Yin F-F, Concus A, Ajlouni M, Benninger MS, Kim JH. Image-guided radiosurgery of head and neck cancers. Otolaryngol Head Neck Surg. 2004 Jun;130(6):690–697.
Journal cover image

Published In

Otolaryngol Head Neck Surg

DOI

ISSN

0194-5998

Publication Date

June 2004

Volume

130

Issue

6

Start / End Page

690 / 697

Location

England

Related Subject Headings

  • Surgery, Computer-Assisted
  • Stereotaxic Techniques
  • Radiosurgery
  • Otorhinolaryngology
  • Humans
  • Head and Neck Neoplasms
  • Follow-Up Studies
  • Dose Fractionation, Radiation
  • Combined Modality Therapy
  • Carcinoma, Squamous Cell