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A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy.

Publication ,  Journal Article
Jin, J-Y; Ajlouni, M; Chen, Q; Yin, F-F; Movsas, B
Published in: Radiother Oncol
February 2006

BACKGROUND AND PURPOSE: To develop and evaluate a technique and procedure of using gated-CT images in combination with PET image to determine the internal target volume (ITV), which could reduce the planning target volume (PTV) with adequate target coverage. PATIENTS AND METHODS: A skin marker-based gating system connected to a regular single slice CT scanner was used for this study. A motion phantom with adjustable motion amplitude was used to evaluate the CT gating system. Specifically, objects of various sizes/shapes, considered as virtual tumors, were placed on the phantom to evaluate the number of phases of gated images required to determine the ITV while taking into account tumor size, shape and motion. A procedure of using gated-CT and PET images to define ITV for patients was developed and was tested in patients enrolled in an IRB approved protocol. RESULTS: The CT gating system was capable of removing motion artifacts for target motion as large as 3-cm when it was gated at optimal phases. A phantom study showed that two gated-CT scans at the end of expiration and the end of inspiration would be sufficient to determine the ITV for tumor motion less than 1-cm, and another mid-phase scan would be required for tumors with 2-cm motion, especially for small tumors. For patients, the ITV encompassing visible tumors in all sets of gated-CT and regular spiral CT images seemed to be consistent with the target volume determined from PET images. PTV expanded from the ITV with a setup uncertainty margin had less volume than PTVs from spiral CT images with a 10-mm generalized margin or an individualized margin determined at fluoroscopy. CONCLUSIONS: A technique of determining the ITV using gated-CT images was developed and was clinically implemented successfully for fractionated stereotactic lung radiotherapy.

Duke Scholars

Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

February 2006

Volume

78

Issue

2

Start / End Page

177 / 184

Location

Ireland

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Spiral Computed
  • Tomography Scanners, X-Ray Computed
  • Stereotaxic Techniques
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Oncology & Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jin, J.-Y., Ajlouni, M., Chen, Q., Yin, F.-F., & Movsas, B. (2006). A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy. Radiother Oncol, 78(2), 177–184. https://doi.org/10.1016/j.radonc.2005.11.012
Jin, Jian-Yue, Munther Ajlouni, Qing Chen, Fang-Fang Yin, and Benjamin Movsas. “A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy.Radiother Oncol 78, no. 2 (February 2006): 177–84. https://doi.org/10.1016/j.radonc.2005.11.012.
Jin J-Y, Ajlouni M, Chen Q, Yin F-F, Movsas B. A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy. Radiother Oncol. 2006 Feb;78(2):177–84.
Jin, Jian-Yue, et al. “A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy.Radiother Oncol, vol. 78, no. 2, Feb. 2006, pp. 177–84. Pubmed, doi:10.1016/j.radonc.2005.11.012.
Jin J-Y, Ajlouni M, Chen Q, Yin F-F, Movsas B. A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy. Radiother Oncol. 2006 Feb;78(2):177–184.
Journal cover image

Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

February 2006

Volume

78

Issue

2

Start / End Page

177 / 184

Location

Ireland

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Spiral Computed
  • Tomography Scanners, X-Ray Computed
  • Stereotaxic Techniques
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Oncology & Carcinogenesis