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An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry.

Publication ,  Journal Article
Velazquez, EJ; Francis, GS; Armstrong, PW; Aylward, PE; Diaz, R; O'Connor, CM; White, HD; Henis, M; Rittenhouse, LM; Kilaru, R; van Gilst, W ...
Published in: Eur Heart J
November 2004

AIMS: We analysed the contemporary incidence, outcomes, and predictors of heart failure (HF) and/or left ventricular systolic dysfunction (LVSD) before discharge in patients with acute myocardial infarction (MI). The baseline presence of HF or LVSD, or its development during hospitalisation, increases short- and long-term risk after MI, yet its incidence, predictors, and outcomes have not been well described in a large, international, general MI population. METHODS AND RESULTS: The VALIANT registry included 5573 consecutive MI patients at 84 hospitals in nine countries from 1999 to 2001. A multivariable logistic survival model was constructed using baseline variables to determine the adjusted mortality risk for those with in-hospital HF and/or LVSD. Baseline variables were also tested for associations with in-hospital HF and/or LVSD. Of the 5566 patients analysed, 42% had HF and/or LVSD during hospitalisation. Their in-hospital mortality rate was 13.0% compared with 2.3% for those without HF and/or without LVSD. After adjustment for other baseline risk factors, in-hospital HF and/or LVSD carried a hazard ratio for in-hospital mortality of 4.12 (95% confidence interval: 3.08-5.56). Patients with HF and/or LVSD also had disproportionately higher rates of other cardiovascular events. CONCLUSIONS: HF and/or LVSD is common in the general contemporary MI population and precedes 80.3% of all in-hospital deaths after MI. Survivors of early MI-associated HF and/or LVSD have more complications, longer hospitalisations, and are more likely to die during hospitalisation. Although baseline variables can identify MI patients at highest risk for HF and/or LVSD, such patients are less likely to receive indicated procedures and medical therapies.

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Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

November 2004

Volume

25

Issue

21

Start / End Page

1911 / 1919

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Registries
  • Myocardial Infarction
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Logistic Models
  • Length of Stay
  • Humans
  • Hospital Mortality
 

Citation

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Velazquez, E. J., Francis, G. S., Armstrong, P. W., Aylward, P. E., Diaz, R., O’Connor, C. M., … VALIANT registry, . (2004). An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. Eur Heart J, 25(21), 1911–1919. https://doi.org/10.1016/j.ehj.2004.08.006
Velazquez, Eric J., Gary S. Francis, Paul W. Armstrong, Phillip E. Aylward, Rafael Diaz, Christopher M. O’Connor, Harvey D. White, et al. “An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry.Eur Heart J 25, no. 21 (November 2004): 1911–19. https://doi.org/10.1016/j.ehj.2004.08.006.
Velazquez EJ, Francis GS, Armstrong PW, Aylward PE, Diaz R, O’Connor CM, et al. An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. Eur Heart J. 2004 Nov;25(21):1911–9.
Velazquez, Eric J., et al. “An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry.Eur Heart J, vol. 25, no. 21, Nov. 2004, pp. 1911–19. Pubmed, doi:10.1016/j.ehj.2004.08.006.
Velazquez EJ, Francis GS, Armstrong PW, Aylward PE, Diaz R, O’Connor CM, White HD, Henis M, Rittenhouse LM, Kilaru R, van Gilst W, Ertl G, Maggioni AP, Spac J, Weaver WD, Rouleau J-L, McMurray JJV, Pfeffer MA, Califf RM, VALIANT registry. An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. Eur Heart J. 2004 Nov;25(21):1911–1919.
Journal cover image

Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

November 2004

Volume

25

Issue

21

Start / End Page

1911 / 1919

Location

England

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Registries
  • Myocardial Infarction
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Logistic Models
  • Length of Stay
  • Humans
  • Hospital Mortality