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Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function.

Publication ,  Journal Article
O'Connor, CM; Gattis, WA; Shaw, L; Cuffe, MS; Califf, RM
Published in: Am J Cardiol
October 15, 2000

Although the syndrome of heart failure with preserved systolic function may occur in up to 40% of all heart failure patients, the clinical, angiographic characteristics, and long-term outcomes of these patients are poorly understood. We prospectively evaluated 2,498 consecutive patients with New York Heart Association class II to IV symptoms and ejection fractions of >40%, who underwent cardiac catheterization between January 1984 and December 1996 at Duke University Medical Center. The median age for the entire cohort was 63 years; 25% of the population was >71 years old. In addition, 55% of the patients were women, 65% had ischemic heart disease, 28% had a history of diabetes, and 62% had a history of hypertension. The median ejection fraction was 58%. One third of the patients had multivessel disease by coronary angiography. The overall 5-year mortality of the total population was 28%. The independent predictors of mortality (p <0.05) using a multivariable Cox proportional hazard model were age, class IV symptoms, ejection fraction, coronary artery disease index, diabetes, peripheral vascular disease, and minority ethnic group. Heart failure with preserved systolic function is characterized by unique clinical and angiographic characteristics associated with a 5-year mortality rate of 28%. Furthermore, several clinical and angiographic characteristics are predictive of long-term survival.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 15, 2000

Volume

86

Issue

8

Start / End Page

863 / 867

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Systole
  • Survival Analysis
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Coronary Angiography
 

Citation

APA
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ICMJE
MLA
NLM
O’Connor, C. M., Gattis, W. A., Shaw, L., Cuffe, M. S., & Califf, R. M. (2000). Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function. Am J Cardiol, 86(8), 863–867. https://doi.org/10.1016/s0002-9149(00)01107-3
O’Connor, C. M., W. A. Gattis, L. Shaw, M. S. Cuffe, and R. M. Califf. “Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function.Am J Cardiol 86, no. 8 (October 15, 2000): 863–67. https://doi.org/10.1016/s0002-9149(00)01107-3.
O’Connor CM, Gattis WA, Shaw L, Cuffe MS, Califf RM. Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function. Am J Cardiol. 2000 Oct 15;86(8):863–7.
O’Connor, C. M., et al. “Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function.Am J Cardiol, vol. 86, no. 8, Oct. 2000, pp. 863–67. Pubmed, doi:10.1016/s0002-9149(00)01107-3.
O’Connor CM, Gattis WA, Shaw L, Cuffe MS, Califf RM. Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function. Am J Cardiol. 2000 Oct 15;86(8):863–867.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 15, 2000

Volume

86

Issue

8

Start / End Page

863 / 867

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Systole
  • Survival Analysis
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
  • Coronary Angiography