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Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease.

Publication ,  Journal Article
Aguilar, D; Fisher, MR; O'Connor, CM; Dunne, MW; Muhlestein, JB; Yao, L; Gupta, S; Benner, RJ; Cook, TD; Edwards, D; Pfeffer, MA ...
Published in: Am Heart J
August 2006

BACKGROUND: The prognosis associated with metabolic syndrome and high-sensitivity C-reactive protein (hs-CRP) in patients with stable coronary artery disease has not been well established. METHODS: The WIZARD study was to determine the effects of 12 weeks of antibiotic therapy on coronary heart disease events in patients with stable coronary artery disease and known Chlamydia pneumoniae exposure. Baseline metabolic risk factors were available for 3319 patients enrolled from 1997 to 1998. The primary outcome was the first occurrence of death, recurrent myocardial infarction, coronary revascularization procedure, or hospitalization for angina. RESULTS: Of the 3319 subjects, 825 patients experienced the primary outcome during the mean follow-up of 37 months. For the composite outcome, there was an increased hazard ratio (HR) for metabolic syndrome (HR 1.40, 95% CI 1.22-1.61) (unadjusted) and for hs-CRP (HR 1.60, 95% CI 1.38-1.85) (unadjusted). Both the metabolic syndrome and hs-CRP indicated, in a multivariable model including age and sex, an increased HR for the primary outcome (metabolic syndrome: HR 1.33, 95% CI 1.15-1.53; hs-CRP: HR 1.52, 95% CI 1.30-1.76). CONCLUSIONS: Although related, the presence of the metabolic syndrome and increased levels of hs-CRP were associated with increased risk of adverse cardiovascular outcomes.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

August 2006

Volume

152

Issue

2

Start / End Page

298 / 304

Location

United States

Related Subject Headings

  • Triglycerides
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Hypertension
 

Citation

APA
Chicago
ICMJE
MLA
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Aguilar, D., Fisher, M. R., O’Connor, C. M., Dunne, M. W., Muhlestein, J. B., Yao, L., … Investigators in the Weekly Intervention with Zithromax for Atherosclerosis and its Related Disorder  study, . (2006). Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease. Am Heart J, 152(2), 298–304. https://doi.org/10.1016/j.ahj.2005.11.011
Aguilar, David, Marian R. Fisher, Christopher M. O’Connor, Michael W. Dunne, Joseph B. Muhlestein, Louis Yao, Sandeep Gupta, et al. “Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease.Am Heart J 152, no. 2 (August 2006): 298–304. https://doi.org/10.1016/j.ahj.2005.11.011.
Aguilar D, Fisher MR, O’Connor CM, Dunne MW, Muhlestein JB, Yao L, et al. Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease. Am Heart J. 2006 Aug;152(2):298–304.
Aguilar, David, et al. “Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease.Am Heart J, vol. 152, no. 2, Aug. 2006, pp. 298–304. Pubmed, doi:10.1016/j.ahj.2005.11.011.
Aguilar D, Fisher MR, O’Connor CM, Dunne MW, Muhlestein JB, Yao L, Gupta S, Benner RJ, Cook TD, Edwards D, Pfeffer MA, Investigators in the Weekly Intervention with Zithromax for Atherosclerosis and its Related Disorder  study. Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease. Am Heart J. 2006 Aug;152(2):298–304.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

August 2006

Volume

152

Issue

2

Start / End Page

298 / 304

Location

United States

Related Subject Headings

  • Triglycerides
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Hypertension