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Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.

Publication ,  Journal Article
Piccini, JP; Starr, AZ; Horton, JR; Shaw, LK; Lee, KL; Al-Khatib, SM; Iskandrian, AE; O'Connor, CM; Borges-Neto, S
Published in: J Am Coll Cardiol
July 13, 2010

OBJECTIVES: The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF)>35%. BACKGROUND: Most victims of SCD have an LVEF>35%. METHODS: The study population included 4,865 patients with CAD and LVEF>35% who underwent gated SPECT MPI. We used Cox proportional hazard modeling to examine the relationship between patient characteristics and SCD. RESULTS: The median age of the population was 63 years (25th, 75th percentile: 54, 71 years), and the median LVEF was 56% (25th, 75th percentile: 50%, 64%). The median follow-up for all patients was 6.5 years (25th, 75th percentile: 3.6, 9.3 years). During follow-up, there were 161 SCDs (3.3%). After multivariable adjustment, LVEF, the Charlson index, hypertension, smoking, antiarrhythmic drug therapy, and the summed stress score (SSS) were associated with SCD (all p<0.05). For each 3-U increase in the SSS, the hazard ratio for SCD was 1.13 (95% confidence interval: 1.04 to 1.23). The addition of perfusion data to the clinical history and LVEF was associated with increased discrimination for SCD events (c-index 0.728). Risk stratification with a derived SPECT nomogram did not result in statistically significant net reclassification improvement (p=0.26) or integrated discrimination improvement (p=0.38). CONCLUSIONS: Among patients with CAD and LVEF>35%, the extent of stress MPI perfusion defects is associated with an increased risk of SCD. Future large prospective studies should address the role of perfusion imaging in the identification of high-risk patients with LVEF>35% who might benefit from ICD implantation.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

July 13, 2010

Volume

56

Issue

3

Start / End Page

206 / 214

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Stroke Volume
  • Myocardial Perfusion Imaging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Death, Sudden, Cardiac
  • Coronary Disease
 

Citation

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Piccini, J. P., Starr, A. Z., Horton, J. R., Shaw, L. K., Lee, K. L., Al-Khatib, S. M., … Borges-Neto, S. (2010). Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%. J Am Coll Cardiol, 56(3), 206–214. https://doi.org/10.1016/j.jacc.2010.01.061
Piccini, Jonathan P., Aijing Z. Starr, John R. Horton, Linda K. Shaw, Kerry L. Lee, Sana M. Al-Khatib, Ami E. Iskandrian, Christopher M. O’Connor, and Salvador Borges-Neto. “Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.J Am Coll Cardiol 56, no. 3 (July 13, 2010): 206–14. https://doi.org/10.1016/j.jacc.2010.01.061.
Piccini, Jonathan P., et al. “Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.J Am Coll Cardiol, vol. 56, no. 3, July 2010, pp. 206–14. Pubmed, doi:10.1016/j.jacc.2010.01.061.
Piccini JP, Starr AZ, Horton JR, Shaw LK, Lee KL, Al-Khatib SM, Iskandrian AE, O’Connor CM, Borges-Neto S. Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%. J Am Coll Cardiol. 2010 Jul 13;56(3):206–214.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

July 13, 2010

Volume

56

Issue

3

Start / End Page

206 / 214

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Stroke Volume
  • Myocardial Perfusion Imaging
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Death, Sudden, Cardiac
  • Coronary Disease