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Prognostic value of anxiety and depression in patients with chronic heart failure.

Publication ,  Journal Article
Jiang, W; Kuchibhatla, M; Cuffe, MS; Christopher, EJ; Alexander, JD; Clary, GL; Blazing, MA; Gaulden, LH; Califf, RM; Krishnan, RR; O'Connor, CM
Published in: Circulation
November 30, 2004

BACKGROUND: Anxiety is often present with depression and may be one of its manifestations. Although the adverse effects of depression in patients with chronic heart failure (CHF) have been well studied, the relation between anxiety and CHF prognosis has not been addressed. In a secondary analysis of data collected for a published study of depression and prognosis in patients with CHF, we examined the relations among anxiety, depression, and prognosis. METHODS AND RESULTS: We measured symptoms of anxiety with the Spielberger State-Trait Anxiety Inventory (STAI) scale and symptoms of depression with the Beck Depression Inventory (BDI) scale in 291 patients with CHF hospitalized as a result of cardiac events. We followed up these patients for all-cause mortality over 1 year. The mean scores for state anxiety (State-A) and trait anxiety (Trait-A) were identical at 33.5; the mean BDI score was 8.7+/-7.6. State-A and Trait-A scores correlated highly with each other (r=0.85; P<0.01) and with BDI score (State-A, r=0.52; Trait-A, r=0.59; P<0.01). Cox proportional-hazards model with and without confounding variables showed no relation between State-A or Trait-A and 1-year mortality. BDI scores, however, significantly predicted increased mortality during 1-year follow-up (hazard ratio, 1.04 for each 1-unit increase; P<0.01). CONCLUSIONS: Although anxiety and depression are highly correlated in CHF patients, depression alone predicts a significantly worse prognosis for these patients.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 30, 2004

Volume

110

Issue

22

Start / End Page

3452 / 3456

Location

United States

Related Subject Headings

  • Stroke Volume
  • Severity of Illness Index
  • Psychological Tests
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Follow-Up Studies
 

Citation

APA
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ICMJE
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Jiang, W., Kuchibhatla, M., Cuffe, M. S., Christopher, E. J., Alexander, J. D., Clary, G. L., … O’Connor, C. M. (2004). Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation, 110(22), 3452–3456. https://doi.org/10.1161/01.CIR.0000148138.25157.F9
Jiang, Wei, Maragatha Kuchibhatla, Michael S. Cuffe, Eric J. Christopher, Jude D. Alexander, Greg L. Clary, Michael A. Blazing, et al. “Prognostic value of anxiety and depression in patients with chronic heart failure.Circulation 110, no. 22 (November 30, 2004): 3452–56. https://doi.org/10.1161/01.CIR.0000148138.25157.F9.
Jiang W, Kuchibhatla M, Cuffe MS, Christopher EJ, Alexander JD, Clary GL, et al. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation. 2004 Nov 30;110(22):3452–6.
Jiang, Wei, et al. “Prognostic value of anxiety and depression in patients with chronic heart failure.Circulation, vol. 110, no. 22, Nov. 2004, pp. 3452–56. Pubmed, doi:10.1161/01.CIR.0000148138.25157.F9.
Jiang W, Kuchibhatla M, Cuffe MS, Christopher EJ, Alexander JD, Clary GL, Blazing MA, Gaulden LH, Califf RM, Krishnan RR, O’Connor CM. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation. 2004 Nov 30;110(22):3452–3456.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 30, 2004

Volume

110

Issue

22

Start / End Page

3452 / 3456

Location

United States

Related Subject Headings

  • Stroke Volume
  • Severity of Illness Index
  • Psychological Tests
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Follow-Up Studies