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Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Publication ,  Journal Article
Wu, QJ; Meyer, J; Fuller, J; Godfrey, D; Wang, Z; Zhang, J; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
January 1, 2011

PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath-hold, whereas BH-CBCT is usually acquired by parsing the gantry rotation into multiple BH segments. This study evaluates the localization accuracy of DTS for BH treatment of liver tumors. METHODS: Both planning CT and on-board DTS/CBCT images were acquired under BH, using the planning CT BH window as reference. Onboard imaging data sets included two independent DTS orientations (coronal and sagittal), and CBCT images. Soft tissue target positioning was measured by each imaging modality and translated into couch shifts. Performance of the two DTS orientations was evaluated by comparing target positioning with the CBCT benchmark, determined by two observers. RESULTS: Image data sets were collected from thirty-eight treatment fractions (14 patients). Mean differences between the two DTS methods and the CBCT method were <1 mm in all directions (except the lateral direction with sagittal-DTS: 1.2 mm); the standard deviation was in the range of 2.1-3.5 mm for all techniques. The Pearson correlation showed good interobserver agreement for the coronal-DTS (0.72-0.78). The interobserver agreement for the sagittal-DTS was good for the in-plane directions (0.70-0.82), but poor in the out-of-plane direction (lateral, 0.26). CONCLUSIONS: BH-DTS may be a simpler alternative to BH-CBCT for onboard soft tissue localization of the liver, although the precision of DTS localization appears to be somewhat lower because of the presence of subtle out-of-plane blur.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

January 1, 2011

Volume

79

Issue

1

Start / End Page

289 / 296

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy Planning, Computer-Assisted
  • Oncology & Carcinogenesis
  • Observer Variation
  • Movement
  • Liver Neoplasms
  • Humans
  • Feasibility Studies
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics
 

Citation

APA
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ICMJE
MLA
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Wu, Q. J., Meyer, J., Fuller, J., Godfrey, D., Wang, Z., Zhang, J., & Yin, F.-F. (2011). Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance. Int J Radiat Oncol Biol Phys, 79(1), 289–296. https://doi.org/10.1016/j.ijrobp.2010.01.047
Wu, Q Jackie, Jeffrey Meyer, Jessica Fuller, Devon Godfrey, Zhiheng Wang, Junan Zhang, and Fang-Fang Yin. “Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.Int J Radiat Oncol Biol Phys 79, no. 1 (January 1, 2011): 289–96. https://doi.org/10.1016/j.ijrobp.2010.01.047.
Wu QJ, Meyer J, Fuller J, Godfrey D, Wang Z, Zhang J, et al. Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance. Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):289–96.
Wu, Q. Jackie, et al. “Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.Int J Radiat Oncol Biol Phys, vol. 79, no. 1, Jan. 2011, pp. 289–96. Pubmed, doi:10.1016/j.ijrobp.2010.01.047.
Wu QJ, Meyer J, Fuller J, Godfrey D, Wang Z, Zhang J, Yin F-F. Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance. Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):289–296.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

January 1, 2011

Volume

79

Issue

1

Start / End Page

289 / 296

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy Planning, Computer-Assisted
  • Oncology & Carcinogenesis
  • Observer Variation
  • Movement
  • Liver Neoplasms
  • Humans
  • Feasibility Studies
  • Cone-Beam Computed Tomography
  • 5105 Medical and biological physics