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Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.

Publication ,  Journal Article
Wu, QJ; Yoo, S; Kirkpatrick, JP; Thongphiew, D; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
December 1, 2009

PURPOSE: This clinical study evaluates the feasibility of using volumetric arc-modulated treatment (VMAT) for spine stereotactic body radiotherapy (SBRT) to achieve highly conformal dose distributions that spare adjacent organs at risk (OAR) with reduced treatment time. METHODS AND MATERIALS: Ten spine SBRT patients were studied retrospectively. The intensity-modulated radiotherapy (IMRT) and VMAT plans were generated using either one or two arcs. Planning target volume (PTV) dose coverage, OAR dose sparing, and normal tissue integral dose were measured and compared. Differences in treatment delivery were also analyzed. RESULTS: The PTV DVHs were comparable between VMAT and IMRT plans in the shoulder (D(99%)-D(90%)), slope (D(90%)-D(10%)), and tail (D(10%)-D(1%)) regions. Only VMAT(2arc) had a better conformity index than IMRT (1.09 vs. 1.15, p = 0.007). For cord sparing, IMRT was the best, and VMAT(1arc) was the worst. Use of IMRT achieved greater than 10% more D(1%) sparing for six of 10 cases and 7% to 15% more D(10%) sparing over the VAMT(1arc). The differences between IMRT and VAMT(2arc) were smaller and statistically nonsignificant at all dose levels. The differences were also small and statistically nonsignificant for other OAR sparing. The mean monitor units (MUs) were 8711, 7730, and 6317 for IMRT, VMAT(1arc), and VMAT(2arc) plans, respectively, with a 26% reduction from IMRT to VMAT(2arc). The mean treatment time was 15.86, 8.56, and 7.88 min for IMRT, VMAT(1arc,) and VMAT(2arc). The difference in integral dose was statistically nonsignificant. CONCLUSIONS: Although VMAT provided comparable PTV coverage for spine SBRT, 1arc showed significantly worse spinal cord sparing compared with IMRT, whereas 2arc was comparable to IMRT. Treatment efficiency is substantially improved with the VMAT.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

December 1, 2009

Volume

75

Issue

5

Start / End Page

1596 / 1604

Location

United States

Related Subject Headings

  • Technology, Radiologic
  • Statistics, Nonparametric
  • Spinal Neoplasms
  • Spinal Cord
  • Retrospective Studies
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiosurgery
  • Radionuclide Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, Q. J., Yoo, S., Kirkpatrick, J. P., Thongphiew, D., & Yin, F.-F. (2009). Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment. Int J Radiat Oncol Biol Phys, 75(5), 1596–1604. https://doi.org/10.1016/j.ijrobp.2009.05.005
Wu, Q Jackie, Sua Yoo, John P. Kirkpatrick, Danthai Thongphiew, and Fang-Fang Yin. “Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.Int J Radiat Oncol Biol Phys 75, no. 5 (December 1, 2009): 1596–1604. https://doi.org/10.1016/j.ijrobp.2009.05.005.
Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin F-F. Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1596–604.
Wu, Q. Jackie, et al. “Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment.Int J Radiat Oncol Biol Phys, vol. 75, no. 5, Dec. 2009, pp. 1596–604. Pubmed, doi:10.1016/j.ijrobp.2009.05.005.
Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin F-F. Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1596–1604.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

December 1, 2009

Volume

75

Issue

5

Start / End Page

1596 / 1604

Location

United States

Related Subject Headings

  • Technology, Radiologic
  • Statistics, Nonparametric
  • Spinal Neoplasms
  • Spinal Cord
  • Retrospective Studies
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiosurgery
  • Radionuclide Imaging