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Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Publication ,  Journal Article
Zhang, J; Wu, QJ; Godfrey, DJ; Fatunase, T; Marks, LB; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
March 1, 2009

PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). METHODS AND MATERIALS: Ten patients who underwent APBI were scanned daily with on-board CBCT. A subset of the CBCT projections was used to reconstruct a stack of DTS image slices. To optimize soft-tissue visibility, the DTS images were reconstructed in oblique directions so that the tumor bed, breast tissue, ribs, and lungs were well separated. Coronal and sagittal DTS images were also reconstructed. Translational shifts of DTS images were obtained on different days from the same patients and were compared with the translational shifts of corresponding CBCT images. Seventy-seven CBCT scans and 291 DTS scans were obtained from nine evaluable patients. RESULTS: Tumor beds were best visible in the oblique DTS scans. One-dimensional positioning differences between DTS and CBCT images were 0.8-1.7 mm for the six patients with clips present and 1.2-2.0 mm for the three patients without clips. Because of the limited DTS scan angle, the DTS registration accuracy along the off-plane direction is lower than the accuracy along the in-plane directions. CONCLUSIONS: For patients receiving APBI, DTS localization offers comparable accuracy to CBCT localization for daily patient positioning while reducing mechanical constraints and imaging dose.

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2009

Volume

73

Issue

3

Start / End Page

952 / 957

Location

United States

Related Subject Headings

  • Radiotherapy Dosage
  • Radiographic Image Enhancement
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Observer Variation
  • Imaging, Three-Dimensional
  • Humans
  • Female
  • Equipment Design
  • Cone-Beam Computed Tomography
 

Citation

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Zhang, J., Wu, Q. J., Godfrey, D. J., Fatunase, T., Marks, L. B., & Yin, F.-F. (2009). Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation. Int J Radiat Oncol Biol Phys, 73(3), 952–957. https://doi.org/10.1016/j.ijrobp.2008.10.036
Zhang, Junan, Q Jackie Wu, Devon J. Godfrey, Toyosi Fatunase, Lawrence B. Marks, and Fang-Fang Yin. “Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.Int J Radiat Oncol Biol Phys 73, no. 3 (March 1, 2009): 952–57. https://doi.org/10.1016/j.ijrobp.2008.10.036.
Zhang J, Wu QJ, Godfrey DJ, Fatunase T, Marks LB, Yin F-F. Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):952–7.
Zhang, Junan, et al. “Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.Int J Radiat Oncol Biol Phys, vol. 73, no. 3, Mar. 2009, pp. 952–57. Pubmed, doi:10.1016/j.ijrobp.2008.10.036.
Zhang J, Wu QJ, Godfrey DJ, Fatunase T, Marks LB, Yin F-F. Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):952–957.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 1, 2009

Volume

73

Issue

3

Start / End Page

952 / 957

Location

United States

Related Subject Headings

  • Radiotherapy Dosage
  • Radiographic Image Enhancement
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Observer Variation
  • Imaging, Three-Dimensional
  • Humans
  • Female
  • Equipment Design
  • Cone-Beam Computed Tomography