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The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy.

Publication ,  Journal Article
Yan, H; Yin, F-F
Published in: J Appl Clin Med Phys
April 16, 2008

In inverse planning for intensity-modulated radiation therapy (IMRT), the dose specification and related weighting factor of an objective function for involved organs is usually predefined by a single value and then iteratively optimized, subject to a set of dose-volume constraints. Because the actual dose distribution is essentially non-uniform and considerably affected by the geometric shape and distribution of the anatomic structures involved, the spatial information regarding those structures should be incorporated such that the predefined parameter distribution is made to approach the clinically expected distribution. Ideally, these parameter distributions should be predefined on a voxel basis in a manual method. However, such an approach is too time-consuming to be feasible in routine use. In the present study, we developed a computer-aided method to achieve the goal described above, producing a non-uniform parameter distribution based on spatial information about the anatomic structures involved. The method consists of two steps: Use distance transformation technique to calculate the distance distribution of the structures. Based on the distance distribution, produce the parameter distribution via a function guided by prior knowledge. We use two simulated cases to examine the effectiveness of the method. The results indicate that application of a non-uniform parameter distribution produced by distance transformation clearly improves dose-sparing of critical organs without compromising dose coverage of the planning target.

Duke Scholars

Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

April 16, 2008

Volume

9

Issue

2

Start / End Page

30 / 45

Location

United States

Related Subject Headings

  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Algorithms
  • 5105 Medical and biological physics
  • 3208 Medical physiology
  • 1116 Medical Physiology
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences
 

Citation

APA
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ICMJE
MLA
NLM
Yan, H., & Yin, F.-F. (2008). The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy. J Appl Clin Med Phys, 9(2), 30–45. https://doi.org/10.1120/jacmp.v9i2.2750
Yan, Hui, and Fang-Fang Yin. “The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy.J Appl Clin Med Phys 9, no. 2 (April 16, 2008): 30–45. https://doi.org/10.1120/jacmp.v9i2.2750.
Yan, Hui, and Fang-Fang Yin. “The application of distance transformation on parameter optimization of inverse planning in intensity-modulated radiation therapy.J Appl Clin Med Phys, vol. 9, no. 2, Apr. 2008, pp. 30–45. Pubmed, doi:10.1120/jacmp.v9i2.2750.

Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

April 16, 2008

Volume

9

Issue

2

Start / End Page

30 / 45

Location

United States

Related Subject Headings

  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Algorithms
  • 5105 Medical and biological physics
  • 3208 Medical physiology
  • 1116 Medical Physiology
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences