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Stereotactic body radiotherapy treatment of extracranial metastases.

Publication ,  Journal Article
Salama, JK; Kirkpatrick, JP; Yin, F-F
Published in: Nat Rev Clin Oncol
November 2012

Radiotherapy is an integral treatment for patients with metastatic cancer, although it is usually reserved for palliation of pain, dyspnoea, oedema, bleeding and neurological symptoms. However, the administration of high-precision radiotherapy, termed stereotactic body radiotherapy (SBRT), has the potential to significantly affect the disease course for some patients with metastatic cancer by delivering high doses of radiation to the secondary tumours with limited high-dose delivery to adjacent healthy tissues. Indeed, such accurate delivery has been firmly established as a therapy for medically inoperable early-stage non-small-cell lung cancer. To date, the technique has demonstrated improvements in controlling metastasis and, in some cases, improved palliation compared with conventionally fractionated radiotherapy. Active areas of research in SBRT include patient selection for curative intent, optimization of SBRT planning techniques, dosing schema and integration of SBRT into systemic therapies. Given the improvements in cytotoxic and targeted therapies over the past decade, studies testing the careful integration of SBRT into standard systemic therapy regimens are needed. Further investigations are also needed to understand the basic biological mechanisms underlying SBRT because they are likely to be different to those mechanisms in conventional radiotherapy.

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Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

November 2012

Volume

9

Issue

11

Start / End Page

654 / 665

Location

England

Related Subject Headings

  • Radiosurgery
  • Neoplasms
  • Neoplasm Metastasis
  • Humans
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Salama, J. K., Kirkpatrick, J. P., & Yin, F.-F. (2012). Stereotactic body radiotherapy treatment of extracranial metastases. Nat Rev Clin Oncol, 9(11), 654–665. https://doi.org/10.1038/nrclinonc.2012.166
Salama, Joseph K., John P. Kirkpatrick, and Fang-Fang Yin. “Stereotactic body radiotherapy treatment of extracranial metastases.Nat Rev Clin Oncol 9, no. 11 (November 2012): 654–65. https://doi.org/10.1038/nrclinonc.2012.166.
Salama JK, Kirkpatrick JP, Yin F-F. Stereotactic body radiotherapy treatment of extracranial metastases. Nat Rev Clin Oncol. 2012 Nov;9(11):654–65.
Salama, Joseph K., et al. “Stereotactic body radiotherapy treatment of extracranial metastases.Nat Rev Clin Oncol, vol. 9, no. 11, Nov. 2012, pp. 654–65. Pubmed, doi:10.1038/nrclinonc.2012.166.
Salama JK, Kirkpatrick JP, Yin F-F. Stereotactic body radiotherapy treatment of extracranial metastases. Nat Rev Clin Oncol. 2012 Nov;9(11):654–665.

Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

November 2012

Volume

9

Issue

11

Start / End Page

654 / 665

Location

England

Related Subject Headings

  • Radiosurgery
  • Neoplasms
  • Neoplasm Metastasis
  • Humans
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis