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A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.

Publication ,  Journal Article
McGuire, SM; Marks, LB; Yin, FF; Das, SK
Published in: Phys Med Biol
January 21, 2010

Macroaggregated albumin single-photon emission computed tomography (MAA-SPECT) provides a map of the spatial distribution of lung perfusion. Our previous work developed a methodology to use SPECT guidance to reduce the dose to the functional lung in IMRT planning. This study aims to investigate the role of beam arrangement on both low and high doses in the functional lung. In our previous work, nine-beam IMRT plans were generated with and without SPECT guidance and compared for five patients. For the current study, the dose-function histogram (DFH) contribution for each of the nine beams for each patient was calculated. Four beams were chosen based on orientation and DFH contributions to create a SPECT-guided plan that spared the functional lung and maintained target coverage. Four-beam SPECT-guided IMRT plans reduced the F(20) and F(30) values by (16.5 +/- 6.8)% and (6.1 +/- 9.2)%, respectively, when compared to nine-beam conventional IMRT plans. Moreover, the SPECT-4F Plan reduces F(5) and F(13) for all patients by (11.0 +/- 8.2)% and (6.1 +/- 3.6)%, respectively, compared to the SPECT Plan. Using fewer beams in IMRT planning may reduce the amount of functional lung that receives 5 and 13 Gy, a factor that has recently been associated with radiation pneumonitis.

Duke Scholars

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

January 21, 2010

Volume

55

Issue

2

Start / End Page

403 / 416

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Lung Neoplasms
  • Lung
  • Humans
 

Citation

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McGuire, S. M., Marks, L. B., Yin, F. F., & Das, S. K. (2010). A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung. Phys Med Biol, 55(2), 403–416. https://doi.org/10.1088/0031-9155/55/2/005
McGuire, S. M., L. B. Marks, F. F. Yin, and S. K. Das. “A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.Phys Med Biol 55, no. 2 (January 21, 2010): 403–16. https://doi.org/10.1088/0031-9155/55/2/005.
McGuire, S. M., et al. “A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.Phys Med Biol, vol. 55, no. 2, Jan. 2010, pp. 403–16. Pubmed, doi:10.1088/0031-9155/55/2/005.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

January 21, 2010

Volume

55

Issue

2

Start / End Page

403 / 416

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Organ Size
  • Nuclear Medicine & Medical Imaging
  • Lung Neoplasms
  • Lung
  • Humans