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Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

Publication ,  Journal Article
Zhang, F; Hu, J; Kelsey, CR; Yoo, D; Yin, F-F; Cai, J
Published in: Int J Radiat Oncol Biol Phys
November 1, 2012

PURPOSE: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. METHODS AND MATERIALS: Cine MV images of 20 patients acquired during three-dimensional conformal (6-11 beams) SBRT treatments were retrospectively analyzed to extract tumor motion trajectories. For each patient, tumor motion PDFs were generated per fraction (PDF(n)) using three selected "usable" beams. Patients without at least three usable beams were excluded from the study. Fractional PDF reproducibility (R(n)) was calculated as the Dice similarity coefficient between PDF(n) to a "ground-truth" PDF (PDF(g)), which was generated using the selected beams of all fractions. The mean of R(n), labeled as R(m), was calculated for each patient and correlated to the patient's mean tumor motion rang (A(m)). Change of R(m) during the course of SBRT treatments was also evaluated. Intra- and intersubject coefficient of variation (CV) of R(m) and A(m) were determined. RESULTS: Thirteen patients had at least three usable beams and were analyzed. The mean of R(m) was 0.87 (range, 0.84-0.95). The mean of A(m) was 3.18 mm (range, 0.46-7.80 mm). R(m) was found to decrease as A(m) increases following an equation of R(m) = 0.17e(-0.9Am) + 0.84. R(m) also decreased slightly throughout the course of treatments. Intersubject CV of R(m) (0.05) was comparable to intrasubject CV of R(m) (range, 0.02-0.09); intersubject CV of A(m) (0.73) was significantly greater than intrasubject CV of A(m) (range, 0.09-0.24). CONCLUSIONS: Tumor motion PDF can be determined using cine MV images acquired during the treatments. The reproducibility of lung tumor motion PDF decreased exponentially as the tumor motion range increased and decreased slightly throughout the course of the treatments.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 1, 2012

Volume

84

Issue

3

Start / End Page

861 / 866

Location

United States

Related Subject Headings

  • Tumor Burden
  • Retrospective Studies
  • Reproducibility of Results
  • Radiosurgery
  • Probability
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, F., Hu, J., Kelsey, C. R., Yoo, D., Yin, F.-F., & Cai, J. (2012). Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer. Int J Radiat Oncol Biol Phys, 84(3), 861–866. https://doi.org/10.1016/j.ijrobp.2012.01.037
Zhang, Fan, Jing Hu, Chris R. Kelsey, David Yoo, Fang-Fang Yin, and Jing Cai. “Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.Int J Radiat Oncol Biol Phys 84, no. 3 (November 1, 2012): 861–66. https://doi.org/10.1016/j.ijrobp.2012.01.037.
Zhang F, Hu J, Kelsey CR, Yoo D, Yin F-F, Cai J. Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):861–6.
Zhang, Fan, et al. “Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.Int J Radiat Oncol Biol Phys, vol. 84, no. 3, Nov. 2012, pp. 861–66. Pubmed, doi:10.1016/j.ijrobp.2012.01.037.
Zhang F, Hu J, Kelsey CR, Yoo D, Yin F-F, Cai J. Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):861–866.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 1, 2012

Volume

84

Issue

3

Start / End Page

861 / 866

Location

United States

Related Subject Headings

  • Tumor Burden
  • Retrospective Studies
  • Reproducibility of Results
  • Radiosurgery
  • Probability
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Lung Neoplasms