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Genomic impacts of chromosomal inversions in parapatric Drosophila species.

Publication ,  Journal Article
McGaugh, SE; Noor, MAF
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
February 2012

Chromosomal inversions impact genetic variation and facilitate speciation in part by reducing recombination in heterokaryotypes. We generated multiple whole-genome shotgun sequences of the parapatric species pair Drosophila pseudoobscura and Drosophila persimilis and their sympatric outgroup (Drosophila miranda) and compared the average pairwise differences for neutral sites within, just outside and far outside of the three large inversions. Divergence between D. pseudoobscura and D. persimilis is high inside the inversions and in the suppressed recombination regions extending 2.5 Mb outside of inversions, but significantly lower in collinear regions further from the inversions. We observe little evidence of decreased divergence predicted to exist in the centre of inversions, suggesting that gene flow through double crossovers or gene conversion is limited within the inversion, or selection is acting within the inversion to maintain divergence in the face of gene flow. In combination with past studies, we provide evidence that inversions in this system maintain areas of high divergence in the face of hybridization, and have done so for a substantial period of time. The left arm of the X chromosome and chromosome 2 inversions appear to have arisen in the lineage leading to D. persimilis approximately 2 Ma, near the time of the split of D. persimilis-D. pseudoobscura-D. miranda, but likely fixed within D. persimilis much more recently, as diversity within D. persimilis is substantially reduced inside and near these two inversions. We also hypothesize that the inversions in D. persimilis may provide an empirical example of the 'mixed geographical mode' theory of inversion origin and fixation, whereby allopatry and secondary contact both play a role.

Duke Scholars

Published In

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

DOI

EISSN

1471-2970

ISSN

0962-8436

Publication Date

February 2012

Volume

367

Issue

1587

Start / End Page

422 / 429

Related Subject Headings

  • X Chromosome
  • Sympatry
  • Selection, Genetic
  • Reproductive Isolation
  • Genome, Insect
  • Genetic Variation
  • Genetic Speciation
  • Gene Flow
  • Female
  • Evolutionary Biology
 

Citation

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McGaugh, S. E., & Noor, M. A. F. (2012). Genomic impacts of chromosomal inversions in parapatric Drosophila species. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 367(1587), 422–429. https://doi.org/10.1098/rstb.2011.0250
McGaugh, Suzanne E., and Mohamed A. F. Noor. “Genomic impacts of chromosomal inversions in parapatric Drosophila species.Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 367, no. 1587 (February 2012): 422–29. https://doi.org/10.1098/rstb.2011.0250.
McGaugh SE, Noor MAF. Genomic impacts of chromosomal inversions in parapatric Drosophila species. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2012 Feb;367(1587):422–9.
McGaugh, Suzanne E., and Mohamed A. F. Noor. “Genomic impacts of chromosomal inversions in parapatric Drosophila species.Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 367, no. 1587, Feb. 2012, pp. 422–29. Epmc, doi:10.1098/rstb.2011.0250.
McGaugh SE, Noor MAF. Genomic impacts of chromosomal inversions in parapatric Drosophila species. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2012 Feb;367(1587):422–429.
Journal cover image

Published In

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

DOI

EISSN

1471-2970

ISSN

0962-8436

Publication Date

February 2012

Volume

367

Issue

1587

Start / End Page

422 / 429

Related Subject Headings

  • X Chromosome
  • Sympatry
  • Selection, Genetic
  • Reproductive Isolation
  • Genome, Insect
  • Genetic Variation
  • Genetic Speciation
  • Gene Flow
  • Female
  • Evolutionary Biology