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HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.

Publication ,  Journal Article
Bonsignori, M; Alam, SM; Liao, H-X; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA
Published in: Trends Microbiol
November 2012

Attempts to formulate a protective HIV-1 vaccine through classic vaccine design strategies have not been successful. Elicitation of HIV-1-specific broadly neutralizing antibodies (bnAbs) at high titers that are present before exposure might be required to achieve protection. Recently, the application of new technologies has facilitated the study of clonal lineages of HIV-1 envelope (Env) antibodies, which have provided insights into HIV-1 antibody development during infection and upon vaccination. Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design.

Duke Scholars

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Published In

Trends Microbiol

DOI

EISSN

1878-4380

Publication Date

November 2012

Volume

20

Issue

11

Start / End Page

532 / 539

Location

England

Related Subject Headings

  • Microbiology
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • AIDS Vaccines
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

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ICMJE
MLA
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Bonsignori, M., Alam, S. M., Liao, H.-X., Verkoczy, L., Tomaras, G. D., Haynes, B. F., & Moody, M. A. (2012). HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends Microbiol, 20(11), 532–539. https://doi.org/10.1016/j.tim.2012.08.011
Bonsignori, Mattia, S Munir Alam, Hua-Xin Liao, Laurent Verkoczy, Georgia D. Tomaras, Barton F. Haynes, and M Anthony Moody. “HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.Trends Microbiol 20, no. 11 (November 2012): 532–39. https://doi.org/10.1016/j.tim.2012.08.011.
Bonsignori M, Alam SM, Liao H-X, Verkoczy L, Tomaras GD, Haynes BF, et al. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends Microbiol. 2012 Nov;20(11):532–9.
Bonsignori, Mattia, et al. “HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design.Trends Microbiol, vol. 20, no. 11, Nov. 2012, pp. 532–39. Pubmed, doi:10.1016/j.tim.2012.08.011.
Bonsignori M, Alam SM, Liao H-X, Verkoczy L, Tomaras GD, Haynes BF, Moody MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends Microbiol. 2012 Nov;20(11):532–539.
Journal cover image

Published In

Trends Microbiol

DOI

EISSN

1878-4380

Publication Date

November 2012

Volume

20

Issue

11

Start / End Page

532 / 539

Location

England

Related Subject Headings

  • Microbiology
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • AIDS Vaccines
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 0605 Microbiology