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Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults.

Publication ,  Journal Article
Conklin, SM; Gianaros, PJ; Brown, SM; Yao, JK; Hariri, AR; Manuck, SB; Muldoon, MF
Published in: Neuroscience letters
June 2007

In animals, dendritic arborization and levels of brain derived neurotrophic factor are positively associated with intake of the omega-3 fatty acids. Here, we test whether omega-3 fatty acid intake in humans varies with individual differences in gray matter volume, an in vivo, systems-level index of neuronal integrity.Fifty-five healthy adults completed two 24h dietary recall interviews. Intake of long-chain omega-3 fatty acids was categorized by tertiles. Regional gray matter volumes in a putative emotional brain circuitry comprised of the anterior cingulate cortex (ACC), amygdala and hippocampus were calculated using optimized voxel-based morphometry on high-resolution structural magnetic resonance images.Region of interest analyses revealed positive associations between reported dietary omega-3 intake and gray matter volume in the subgenual ACC, the right hippocampus and the right amygdala, adjusted for total gray matter volume of brain. Unconstrained whole-brain analyses confirmed that higher intake of omega-3 fatty acids was selectively associated with increased greater gray matter volume in these and not other regions.Higher reported consumption of the long-chain omega-3 fatty acids is associated with greater gray matter volume in nodes of a corticolimbic circuitry supporting emotional arousal and regulation. Such associations may mediate previously observed effects of omega-3 fatty acids on memory, mood and affect regulation.

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Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

June 2007

Volume

421

Issue

3

Start / End Page

209 / 212

Related Subject Headings

  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Humans
  • Female
  • Fatty Acids, Omega-3
  • Cerebral Cortex
  • Brain Mapping
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Conklin, S. M., Gianaros, P. J., Brown, S. M., Yao, J. K., Hariri, A. R., Manuck, S. B., & Muldoon, M. F. (2007). Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neuroscience Letters, 421(3), 209–212. https://doi.org/10.1016/j.neulet.2007.04.086
Conklin, Sarah M., Peter J. Gianaros, Sarah M. Brown, Jeffrey K. Yao, Ahmad R. Hariri, Stephen B. Manuck, and Matthew F. Muldoon. “Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults.Neuroscience Letters 421, no. 3 (June 2007): 209–12. https://doi.org/10.1016/j.neulet.2007.04.086.
Conklin SM, Gianaros PJ, Brown SM, Yao JK, Hariri AR, Manuck SB, et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neuroscience letters. 2007 Jun;421(3):209–12.
Conklin, Sarah M., et al. “Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults.Neuroscience Letters, vol. 421, no. 3, June 2007, pp. 209–12. Epmc, doi:10.1016/j.neulet.2007.04.086.
Conklin SM, Gianaros PJ, Brown SM, Yao JK, Hariri AR, Manuck SB, Muldoon MF. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neuroscience letters. 2007 Jun;421(3):209–212.
Journal cover image

Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

June 2007

Volume

421

Issue

3

Start / End Page

209 / 212

Related Subject Headings

  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Humans
  • Female
  • Fatty Acids, Omega-3
  • Cerebral Cortex
  • Brain Mapping
  • Adult