Skip to main content
Journal cover image

Consensus-based standards for best supportive care in clinical trials in advanced cancer.

Publication ,  Journal Article
Zafar, SY; Currow, DC; Cherny, N; Strasser, F; Fowler, R; Abernethy, AP
Published in: Lancet Oncol
February 2012

Best supportive care is poorly defined in clinical trials, and a standard framework for delivery of such care is needed, using best available evidence and allowing replication of studies. We convened a panel of 36 experts to develop consensus statements via the Delphi method. The first round included open-ended questions; subsequent rounds sought to develop consensus-based standards. Consensus was assessed by use of a 5-point Likert agreement scale; more than 70% of panellists had to give a score of 5 to meet a-priori levels of consensus. The panel identified four key domains of best supportive care in clinical trials: multidisciplinary care; supportive care documentation; symptom assessment; and symptom management. Consensus was reached on 11 statements within these four domains. For example, 24 (96%) panellists recommended that the intervals between symptom assessments should be identical for control and experimental groups. Availability of resources was cited as a challenge to implementation of best supportive care standards.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lancet Oncol

DOI

EISSN

1474-5488

Publication Date

February 2012

Volume

13

Issue

2

Start / End Page

e77 / e82

Location

England

Related Subject Headings

  • Reference Standards
  • Palliative Care
  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Staging
  • Humans
  • Evidence-Based Practice
  • Delphi Technique
  • Consensus
  • Clinical Trials as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zafar, S. Y., Currow, D. C., Cherny, N., Strasser, F., Fowler, R., & Abernethy, A. P. (2012). Consensus-based standards for best supportive care in clinical trials in advanced cancer. Lancet Oncol, 13(2), e77–e82. https://doi.org/10.1016/S1470-2045(11)70215-7
Zafar, S Yousuf, David C. Currow, Nathan Cherny, Florian Strasser, Robin Fowler, and Amy P. Abernethy. “Consensus-based standards for best supportive care in clinical trials in advanced cancer.Lancet Oncol 13, no. 2 (February 2012): e77–82. https://doi.org/10.1016/S1470-2045(11)70215-7.
Zafar SY, Currow DC, Cherny N, Strasser F, Fowler R, Abernethy AP. Consensus-based standards for best supportive care in clinical trials in advanced cancer. Lancet Oncol. 2012 Feb;13(2):e77–82.
Zafar, S. Yousuf, et al. “Consensus-based standards for best supportive care in clinical trials in advanced cancer.Lancet Oncol, vol. 13, no. 2, Feb. 2012, pp. e77–82. Pubmed, doi:10.1016/S1470-2045(11)70215-7.
Zafar SY, Currow DC, Cherny N, Strasser F, Fowler R, Abernethy AP. Consensus-based standards for best supportive care in clinical trials in advanced cancer. Lancet Oncol. 2012 Feb;13(2):e77–e82.
Journal cover image

Published In

Lancet Oncol

DOI

EISSN

1474-5488

Publication Date

February 2012

Volume

13

Issue

2

Start / End Page

e77 / e82

Location

England

Related Subject Headings

  • Reference Standards
  • Palliative Care
  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Staging
  • Humans
  • Evidence-Based Practice
  • Delphi Technique
  • Consensus
  • Clinical Trials as Topic