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Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host.

Publication ,  Journal Article
Haycox, CL; Kim, S; Fleckman, P; Smith, LT; Piepkorn, M; Sundberg, JP; Howell, DN; Miller, SE
Published in: J Investig Dermatol Symp Proc
December 1999
Published version (DOI) Link to item

This is a case report of an immunocompromised individual who presented with progressive alopecia, friable follicular spinous processes, and erythematous, indurated papules. Examination of skin biopsies using light microscopy and immunohistochemistry revealed pathologic changes of the follicular inner root sheath epithelium with dystrophic trichohyaline granules. Electron microscopy of thin sections of tissue revealed intracellular viral particles with a size and appearance consistent with those in the Papovaviridae family. Electron microscopy of negatively stained extract from a homogenized lesion also demonstrated icosahedral viruses with papovavirus morphology. We believe this is a previously unreported folliculocentric viral infection in an immunosuppressed human host and have termed this entity "trichodysplasia spinulosa".

Duke Scholars

David Noble Howell
Author David Noble Howell Pathology
Sara Elizabeth Miller
Author Sara Elizabeth Miller Pathology
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Published In

J Investig Dermatol Symp Proc

DOI

10.1038/sj.jidsp.5640227

ISSN

1087-0024

Publication Date

December 1999

Volume

4

Issue

3

Start / End Page

268 / 271

Location

United States

Related Subject Headings

  • Papillomavirus Infections
  • Male
  • Immunocompromised Host
  • Humans
  • Hair Follicle
  • Hair Diseases
  • Facial Dermatoses
  • Adult
 

Citation

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Haycox, C. L., Kim, S., Fleckman, P., Smith, L. T., Piepkorn, M., Sundberg, J. P., … Miller, S. E. (1999). Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc, 4(3), 268–271. https://doi.org/10.1038/sj.jidsp.5640227
Haycox, C. L., S. Kim, P. Fleckman, L. T. Smith, M. Piepkorn, J. P. Sundberg, D. N. Howell, and S. E. Miller. “Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host.” J Investig Dermatol Symp Proc 4, no. 3 (December 1999): 268–71. https://doi.org/10.1038/sj.jidsp.5640227.
Haycox CL, Kim S, Fleckman P, Smith LT, Piepkorn M, Sundberg JP, et al. Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc. 1999 Dec;4(3):268–71.
Haycox, C. L., et al. “Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host.” J Investig Dermatol Symp Proc, vol. 4, no. 3, Dec. 1999, pp. 268–71. Pubmed, doi:10.1038/sj.jidsp.5640227.
Haycox CL, Kim S, Fleckman P, Smith LT, Piepkorn M, Sundberg JP, Howell DN, Miller SE. Trichodysplasia spinulosa--a newly described folliculocentric viral infection in an immunocompromised host. J Investig Dermatol Symp Proc. 1999 Dec;4(3):268–271.
Journal cover image

Published In

J Investig Dermatol Symp Proc

DOI

10.1038/sj.jidsp.5640227

ISSN

1087-0024

Publication Date

December 1999

Volume

4

Issue

3

Start / End Page

268 / 271

Location

United States

Related Subject Headings

  • Papillomavirus Infections
  • Male
  • Immunocompromised Host
  • Humans
  • Hair Follicle
  • Hair Diseases
  • Facial Dermatoses
  • Adult