Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Dyskinesias are a common consequence of dopaminergic therapy in patients with Parkinson's disease. Little is known about the influence of cellular replacement strategies upon drug-induced dyskinesias. In the current study, we employed parkinsonian rats to test whether the distribution of dopamine neuron grafts could differentially alter striatal circuitry and levodopa-induced dyskinesias. Specifically, we compared behavioral and neurochemical consequences of dopamine reinnervation restricted to a focal region of the striatum to innervation encompassing the majority of the striatum by distributing the same number of cells into single locus or multiple locations. Both the single-site and widespread grafts reduced pregraft dyskinesias and normalized FosB/DeltaFosB in the dorsal two-thirds of the lateral striatum. However, single-site DA graft recipients developed a robust, novel forelimb-facial stereotypy and upregulated FosB/DeltaFosB expression in the ventrolateral striatum, an area associated with movements of tongue and forelimbs. The onset of forelimb-facial stereotypy correlated with measures of increased graft function.
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- Sympatholytics
- Rats, Inbred F344
- Rats
- Proto-Oncogene Proteins c-fos
- Parkinson Disease
- Oxidopamine
- Neurology & Neurosurgery
- Mesencephalon
- Male
- Fetal Tissue Transplantation
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sympatholytics
- Rats, Inbred F344
- Rats
- Proto-Oncogene Proteins c-fos
- Parkinson Disease
- Oxidopamine
- Neurology & Neurosurgery
- Mesencephalon
- Male
- Fetal Tissue Transplantation