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The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals.

Publication ,  Journal Article
Higginbotham, EJ; Gordon, MO; Beiser, JA; Drake, MV; Bennett, GR; Wilson, MR; Kass, MA; Ocular Hypertension Treatment Study Group,
Published in: Arch Ophthalmol
June 2004

BACKGROUND: The prevalence of glaucoma is higher in African American individuals than in white individuals. OBJECTIVE: To report the safety and efficacy of topical ocular hypotensive medication in delaying or preventing the onset of primary open-angle glaucoma (POAG) among African American participants in the Ocular Hypertension Treatment Study. METHODS: Eligibility criteria included age between 40 and 80 years, intraocular pressure between 24 and 32 mm Hg in one eye and between 21 and 32 mm Hg in the other eye, and no evidence of glaucomatous structural or functional damage by standard clinical measures. Participants were randomized to either the observation group or medication group. Of the 1636 participants randomized, 408 were self-identified as African American. MAIN OUTCOME MEASURE: The primary outcome was the development of reproducible visual field abnormality and/or reproducible optic disc deterioration attributed to POAG. RESULTS: Among African American participants, 17 (8.4%) of 203 in the medication group developed POAG during the study (median follow-up, 78 months) compared with 33 (16.1%) of 205 participants in the observation group (hazard ratio, 0.50; 95% confidence interval, 0.28-0.90; P =.02). CONCLUSION: Topical ocular hypotensive therapy is effective in delaying or preventing the onset of POAG in African American individuals who have ocular hypertension.

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Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

June 2004

Volume

122

Issue

6

Start / End Page

813 / 820

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Safety
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Glaucoma, Open-Angle
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Higginbotham, E. J., Gordon, M. O., Beiser, J. A., Drake, M. V., Bennett, G. R., Wilson, M. R., … Ocular Hypertension Treatment Study Group, . (2004). The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch Ophthalmol, 122(6), 813–820. https://doi.org/10.1001/archopht.122.6.813
Higginbotham, Eve J., Mae O. Gordon, Julia A. Beiser, Michael V. Drake, G Richard Bennett, M Roy Wilson, Michael A. Kass, and Michael A. Ocular Hypertension Treatment Study Group. “The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals.Arch Ophthalmol 122, no. 6 (June 2004): 813–20. https://doi.org/10.1001/archopht.122.6.813.
Higginbotham EJ, Gordon MO, Beiser JA, Drake MV, Bennett GR, Wilson MR, et al. The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch Ophthalmol. 2004 Jun;122(6):813–20.
Higginbotham, Eve J., et al. “The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals.Arch Ophthalmol, vol. 122, no. 6, June 2004, pp. 813–20. Pubmed, doi:10.1001/archopht.122.6.813.
Higginbotham EJ, Gordon MO, Beiser JA, Drake MV, Bennett GR, Wilson MR, Kass MA, Ocular Hypertension Treatment Study Group. The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch Ophthalmol. 2004 Jun;122(6):813–820.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

June 2004

Volume

122

Issue

6

Start / End Page

813 / 820

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Safety
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Ocular Hypertension
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Glaucoma, Open-Angle