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Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.

Publication ,  Journal Article
Llewellyn, DJ; Lang, IA; Matthews, FE; Plassman, BL; Rogers, MA; Morgenstern, LB; Fisher, GG; Kabeto, MU; Langa, KM
Published in: Alzheimers Res Ther
June 24, 2010

INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon4 to dementia was modelled using adjusted multivariable logistic regression. RESULTS: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon4 and stroke (P = 0.001). CONCLUSIONS: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon4 allele and their interaction are strongly associated with dementia.

Duke Scholars

Published In

Alzheimers Res Ther

DOI

EISSN

1758-9193

Publication Date

June 24, 2010

Volume

2

Issue

3

Start / End Page

19

Location

England

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Llewellyn, D. J., Lang, I. A., Matthews, F. E., Plassman, B. L., Rogers, M. A., Morgenstern, L. B., … Langa, K. M. (2010). Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther, 2(3), 19. https://doi.org/10.1186/alzrt43
Llewellyn, David J., Iain A. Lang, Fiona E. Matthews, Brenda L. Plassman, Mary Am Rogers, Lewis B. Morgenstern, Gwenith G. Fisher, Mohammed U. Kabeto, and Kenneth M. Langa. “Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.Alzheimers Res Ther 2, no. 3 (June 24, 2010): 19. https://doi.org/10.1186/alzrt43.
Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, et al. Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther. 2010 Jun 24;2(3):19.
Llewellyn, David J., et al. “Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.Alzheimers Res Ther, vol. 2, no. 3, June 2010, p. 19. Pubmed, doi:10.1186/alzrt43.
Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM. Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther. 2010 Jun 24;2(3):19.
Journal cover image

Published In

Alzheimers Res Ther

DOI

EISSN

1758-9193

Publication Date

June 24, 2010

Volume

2

Issue

3

Start / End Page

19

Location

England

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences