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Origin of epicardial ST-T wave potentials in the intact dog.

Publication ,  Journal Article
Spach, MS; Barr, RC
Published in: Circulation research
October 1976

Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at each ectopic site. The measured epicardial potentials were simulated by means of a model of ST-T wave events that is suitable for study of single and multiple ectopic beats with fusion, a a model we call 'SI model.' Intracellular potentials around the ventricles during repolarization were calculated from measured excitation sequences and known action potential shapes. The extracellular potentials around the ventricles were computed from the intracellular ones by a simplified ventricular geometry. The satisfactory agreement between the theoretical and measured extracellular potential distribution shows that the complex changes which occur throughout the ST-T wave are predicted well on the basis of changes in the intracellular potential distributions. In contrast to the well known lability of the T wave from beat, the results show that for any single beat the events of repolarization proceed in an entirely repeatable and deterministic fashion. The results present a way to directly represent cardiac extracellular events during the ST-T wave, a method analogous to the use of isochromes during QRS, and they imply that in the future it will by possible to achieve a more precise quantitative understanding of the events of the ST-T wave than thus far has been possible for QRS.

Duke Scholars

Published In

Circulation research

DOI

EISSN

1524-4571

ISSN

0009-7330

Publication Date

October 1976

Volume

39

Issue

4

Start / End Page

475 / 487

Related Subject Headings

  • Synaptic Transmission
  • Refractory Period, Electrophysiological
  • Myocardial Contraction
  • Models, Biological
  • Membrane Potentials
  • Heart Ventricles
  • Heart Conduction System
  • Heart Atria
  • Evoked Potentials
  • Electric Stimulation
 

Citation

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ICMJE
MLA
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Spach, M. S., & Barr, R. C. (1976). Origin of epicardial ST-T wave potentials in the intact dog. Circulation Research, 39(4), 475–487. https://doi.org/10.1161/01.res.39.4.475
Spach, M. S., and R. C. Barr. “Origin of epicardial ST-T wave potentials in the intact dog.Circulation Research 39, no. 4 (October 1976): 475–87. https://doi.org/10.1161/01.res.39.4.475.
Spach MS, Barr RC. Origin of epicardial ST-T wave potentials in the intact dog. Circulation research. 1976 Oct;39(4):475–87.
Spach, M. S., and R. C. Barr. “Origin of epicardial ST-T wave potentials in the intact dog.Circulation Research, vol. 39, no. 4, Oct. 1976, pp. 475–87. Epmc, doi:10.1161/01.res.39.4.475.
Spach MS, Barr RC. Origin of epicardial ST-T wave potentials in the intact dog. Circulation research. 1976 Oct;39(4):475–487.

Published In

Circulation research

DOI

EISSN

1524-4571

ISSN

0009-7330

Publication Date

October 1976

Volume

39

Issue

4

Start / End Page

475 / 487

Related Subject Headings

  • Synaptic Transmission
  • Refractory Period, Electrophysiological
  • Myocardial Contraction
  • Models, Biological
  • Membrane Potentials
  • Heart Ventricles
  • Heart Conduction System
  • Heart Atria
  • Evoked Potentials
  • Electric Stimulation