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ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.

Publication ,  Journal Article
Guillem, JG; Wood, WC; Moley, JF; Berchuck, A; Karlan, BY; Mutch, DG; Gagel, RF; Weitzel, J; Morrow, M; Weber, BL; Giardiello, F; Church, J ...
Published in: Ann Surg Oncol
October 2006

BACKGROUND: A significant portion of cancers are accounted for by a heritable component, which has increasingly been linked to mutations in specific genes. Clinical interventions have been formulated for mutation carriers within affected families. The primary interventions for mutation carriers of highly penetrant syndromes are surgical. METHODS: The American Society of Clinical Oncology and the Society of Surgical Oncology formed a task force charged with presenting an educational symposium on surgical management of hereditary cancer syndromes at annual society meetings, and this resulted in a position paper on this topic. The content of both the symposium and the position paper was developed as a consensus statement. RESULTS: This article addresses hereditary breast, colorectal, ovarian/endometrial, and multiple endocrine neoplasias. A brief introduction on the genetics and natural history of each disease is provided, followed by detailed descriptions of modern surgical approaches, clinical and genetic indications, timing of prophylactic surgery, and the efficacy of surgery (when known). Although several recent reviews have addressed the role of genetic testing for cancer susceptibility, this article focuses on the issues surrounding surgical technique, timing, and indications for surgical prophylaxis. CONCLUSIONS: Risk-reducing surgical treatment of hereditary cancer is a complex undertaking. It requires a clear understanding of the natural history of the disease, realistic appreciation of the potential benefits and risks of these procedures in potentially otherwise healthy individuals, and the long-term sequelae of such interventions, as well as the individual patient's and family's perceptions of surgical risk and anticipated benefit.

Duke Scholars

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

October 2006

Volume

13

Issue

10

Start / End Page

1296 / 1321

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Societies, Medical
  • Risk Assessment
  • Risk
  • Oncology & Carcinogenesis
  • Neoplastic Syndromes, Hereditary
  • Neoplasms
  • Mutation
  • Medical Oncology
 

Citation

APA
Chicago
ICMJE
MLA
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Guillem, J. G., Wood, W. C., Moley, J. F., Berchuck, A., Karlan, B. Y., Mutch, D. G., … Offit, K. (2006). ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol, 13(10), 1296–1321. https://doi.org/10.1245/s10434-006-9036-6
Guillem, José G., William C. Wood, Jeffrey F. Moley, Andrew Berchuck, Beth Y. Karlan, David G. Mutch, Robert F. Gagel, et al. “ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.Ann Surg Oncol 13, no. 10 (October 2006): 1296–1321. https://doi.org/10.1245/s10434-006-9036-6.
Guillem JG, Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, et al. ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol. 2006 Oct;13(10):1296–321.
Guillem, José G., et al. “ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes.Ann Surg Oncol, vol. 13, no. 10, Oct. 2006, pp. 1296–321. Pubmed, doi:10.1245/s10434-006-9036-6.
Guillem JG, Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, Gagel RF, Weitzel J, Morrow M, Weber BL, Giardiello F, Rodriguez-Bigas MA, Church J, Gruber S, Offit K. ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol. 2006 Oct;13(10):1296–1321.
Journal cover image

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

October 2006

Volume

13

Issue

10

Start / End Page

1296 / 1321

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Societies, Medical
  • Risk Assessment
  • Risk
  • Oncology & Carcinogenesis
  • Neoplastic Syndromes, Hereditary
  • Neoplasms
  • Mutation
  • Medical Oncology