Estimating drug shelf-life with random batches.
Publication
, Journal Article
Chow, SC; Shao, J
Published in: Biometrics
September 1991
The problem of assessing the shelf-lives of drug products in the market is considered. We focus on the situation where the drug characteristic of interest has a linear relationship over time and batch-to-batch variation is present. Two methods for assessing shelf-lives are proposed based on the weighted least squares method under a regression model with random coefficients. An application to some stability data from the pharmaceutical industry is presented.
Duke Scholars
Published In
Biometrics
ISSN
0006-341X
Publication Date
September 1991
Volume
47
Issue
3
Start / End Page
1071 / 1079
Location
England
Related Subject Headings
- United States Food and Drug Administration
- United States
- Time Factors
- Statistics & Probability
- Random Allocation
- Models, Statistical
- Mathematics
- Drug Stability
- 4905 Statistics
- 0199 Other Mathematical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chow, S. C., & Shao, J. (1991). Estimating drug shelf-life with random batches. Biometrics, 47(3), 1071–1079.
Chow, S. C., and J. Shao. “Estimating drug shelf-life with random batches.” Biometrics 47, no. 3 (September 1991): 1071–79.
Chow SC, Shao J. Estimating drug shelf-life with random batches. Biometrics. 1991 Sep;47(3):1071–9.
Chow, S. C., and J. Shao. “Estimating drug shelf-life with random batches.” Biometrics, vol. 47, no. 3, Sept. 1991, pp. 1071–79.
Chow SC, Shao J. Estimating drug shelf-life with random batches. Biometrics. 1991 Sep;47(3):1071–1079.
Published In
Biometrics
ISSN
0006-341X
Publication Date
September 1991
Volume
47
Issue
3
Start / End Page
1071 / 1079
Location
England
Related Subject Headings
- United States Food and Drug Administration
- United States
- Time Factors
- Statistics & Probability
- Random Allocation
- Models, Statistical
- Mathematics
- Drug Stability
- 4905 Statistics
- 0199 Other Mathematical Sciences