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The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes

Publication ,  Journal Article
Chaubet, F; van duong, MN; Gref, A; Courtieu, J; Crumbliss, AL; Gaudemer, A; M. Gross, P
Published in: Tetrahedron Letters
January 1, 1990

We have prepared a series of dihydroxamates and their iron (III) complexes in view of obtaining new NMR imaging agents. Four new dihydroxamic acid ligands have been synthesized by condensation of 4-substituted-2,6-pyridine dicarboxylic acids with N-aminopropyl-N-acetylhydroxylamine, and the iron (III) complexes exhibit high stability over the pH range 3 to 7 and a binuclear structure Fe2L3 at pH7. The presence of two non-interacting paramagnetic centers per mole should allow a good compromise between an efficient relaxivity and limited toxicity. © 1990.

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Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

January 1, 1990

Volume

31

Issue

40

Start / End Page

5729 / 5732

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

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Chaubet, F., van duong, M. N., Gref, A., Courtieu, J., Crumbliss, A. L., Gaudemer, A., & M. Gross, P. (1990). The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes. Tetrahedron Letters, 31(40), 5729–5732. https://doi.org/10.1016/S0040-4039(00)97943-7
Chaubet, F., M. N. van duong, A. Gref, J. Courtieu, A. L. Crumbliss, A. Gaudemer, and P. M. Gross. “The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes.” Tetrahedron Letters 31, no. 40 (January 1, 1990): 5729–32. https://doi.org/10.1016/S0040-4039(00)97943-7.
Chaubet F, van duong MN, Gref A, Courtieu J, Crumbliss AL, Gaudemer A, et al. The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes. Tetrahedron Letters. 1990 Jan 1;31(40):5729–32.
Chaubet, F., et al. “The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes.” Tetrahedron Letters, vol. 31, no. 40, Jan. 1990, pp. 5729–32. Scopus, doi:10.1016/S0040-4039(00)97943-7.
Chaubet F, van duong MN, Gref A, Courtieu J, Crumbliss AL, Gaudemer A, M. Gross P. The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes. Tetrahedron Letters. 1990 Jan 1;31(40):5729–5732.
Journal cover image

Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

January 1, 1990

Volume

31

Issue

40

Start / End Page

5729 / 5732

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry