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Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?

Publication ,  Journal Article
Ghio, AJ; Kennedy, TP; Schapira, RM; Crumbliss, AL; Hoidal, JR
Published in: Lancet (London, England)
October 1990

Inhaled silicate dusts may cause lung disease through their surface coordination of iron with subsequent oxidant generation via the Fenton reaction. Pneumoconiosis, irritant bronchitis, focal emphysema, and carcinoma may be produced by oxidants either directly through lipid peroxidation and protein inactivation, or indirectly by oxidant-mediated release of cytokines such as platelet-derived growth factor. The increased incidence of tuberculosis observed among silicate workers could be explained by accumulation of iron complexed by dust particles in the lung and made available to dormant mycobacteria as a virulence factor.

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Published In

Lancet (London, England)

DOI

EISSN

1474-547X

ISSN

0140-6736

Publication Date

October 1990

Volume

336

Issue

8721

Start / End Page

967 / 969

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Silicosis
  • Silicon Dioxide
  • Oxidation-Reduction
  • Mycobacterium tuberculosis
  • Lung Diseases
  • Lipid Peroxidation
  • Humans
  • General & Internal Medicine
  • Ferric Compounds
 

Citation

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Ghio, A. J., Kennedy, T. P., Schapira, R. M., Crumbliss, A. L., & Hoidal, J. R. (1990). Hypothesis: is lung disease after silicate inhalation caused by oxidant generation? Lancet (London, England), 336(8721), 967–969. https://doi.org/10.1016/0140-6736(90)92421-d
Ghio, A. J., T. P. Kennedy, R. M. Schapira, A. L. Crumbliss, and J. R. Hoidal. “Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?Lancet (London, England) 336, no. 8721 (October 1990): 967–69. https://doi.org/10.1016/0140-6736(90)92421-d.
Ghio AJ, Kennedy TP, Schapira RM, Crumbliss AL, Hoidal JR. Hypothesis: is lung disease after silicate inhalation caused by oxidant generation? Lancet (London, England). 1990 Oct;336(8721):967–9.
Ghio, A. J., et al. “Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?Lancet (London, England), vol. 336, no. 8721, Oct. 1990, pp. 967–69. Epmc, doi:10.1016/0140-6736(90)92421-d.
Ghio AJ, Kennedy TP, Schapira RM, Crumbliss AL, Hoidal JR. Hypothesis: is lung disease after silicate inhalation caused by oxidant generation? Lancet (London, England). 1990 Oct;336(8721):967–969.
Journal cover image

Published In

Lancet (London, England)

DOI

EISSN

1474-547X

ISSN

0140-6736

Publication Date

October 1990

Volume

336

Issue

8721

Start / End Page

967 / 969

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Silicosis
  • Silicon Dioxide
  • Oxidation-Reduction
  • Mycobacterium tuberculosis
  • Lung Diseases
  • Lipid Peroxidation
  • Humans
  • General & Internal Medicine
  • Ferric Compounds