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T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.

Publication ,  Journal Article
Troiano, R; Devereux, C; Oleske, J; Denny, T; Hafstein, M; Zito, G; Rohowski-Kochan, C; Dowling, PC; Cook, SD
Published in: J Neurol Neurosurg Psychiatry
July 1988
Published version (DOI) Link to item

T lymphocyte subset percentages were determined in 16 total lymphoid irradiation (TLI) treated and 18 sham treated control patients with chronic progressive multiple sclerosis. During the first year after treatment, the ratio of T helper/inducer to T suppressor/cytotoxic cells (Th/Ts ratio) was significantly higher in sham treated multiple sclerosis patients who worsened clinically compared with TLI treated and sham treated multiple sclerosis patients who remained clinically stable. TLI caused a fall in the percentage of T helper cells in treated patients, while the percentage of T suppressor cells remained stable during the first year after treatment. In contrast, the percentage of T suppressor cells fell in sham treated multiple sclerosis patients who worsened clinically.

Duke Scholars

Thomas Norton Denny
Author Thomas Norton Denny Medicine, Duke Human Vaccine Institute

Published In

J Neurol Neurosurg Psychiatry

DOI

10.1136/jnnp.51.7.980

ISSN

0022-3050

Publication Date

July 1988

Volume

51

Issue

7

Start / End Page

980 / 983

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Leukocyte Count
  • Immune Tolerance
  • Humans
  • Follow-Up Studies
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Troiano, R., Devereux, C., Oleske, J., Denny, T., Hafstein, M., Zito, G., … Cook, S. D. (1988). T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. J Neurol Neurosurg Psychiatry, 51(7), 980–983. https://doi.org/10.1136/jnnp.51.7.980
Troiano, R., C. Devereux, J. Oleske, T. Denny, M. Hafstein, G. Zito, C. Rohowski-Kochan, P. C. Dowling, and S. D. Cook. “T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.” J Neurol Neurosurg Psychiatry 51, no. 7 (July 1988): 980–83. https://doi.org/10.1136/jnnp.51.7.980.
Troiano R, Devereux C, Oleske J, Denny T, Hafstein M, Zito G, et al. T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):980–3.
Troiano, R., et al. “T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.” J Neurol Neurosurg Psychiatry, vol. 51, no. 7, July 1988, pp. 980–83. Pubmed, doi:10.1136/jnnp.51.7.980.
Troiano R, Devereux C, Oleske J, Denny T, Hafstein M, Zito G, Rohowski-Kochan C, Dowling PC, Cook SD. T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):980–983.

Published In

J Neurol Neurosurg Psychiatry

DOI

10.1136/jnnp.51.7.980

ISSN

0022-3050

Publication Date

July 1988

Volume

51

Issue

7

Start / End Page

980 / 983

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Leukocyte Count
  • Immune Tolerance
  • Humans
  • Follow-Up Studies
  • 3209 Neurosciences