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The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow.

Publication ,  Journal Article
Dewhirst, M; Gross, JF; Sim, D; Arnold, P; Boyer, D
Published in: Biorheology
1984

Single vessel responses to hyperthermia were studied in tumor and normal tissues using a transparent access window chamber. Rates of heating less than or equal to .68 degrees C/minute preserved relatively better vascular function in normal than tumor tissue. A rate of heating of 1.0 degrees C/minute lowered normal tissue statis temperatures so they were no different from tumor. Cooling to 30 degrees C prior to heating slowed normal arteriolar flows to less than 5% of 38 degrees C controls. Heating resulted in increased flow in those vessels, but maximum flows never exceeded 5% of flows achieved in similar vessels which were not cooled first. The implications of this work are that rate of heating and cooling prior to heating can alter normal tissue vascular response to heat in a way that could prove deleterious to maintaining efficient vascular function in that tissue relative to tumor.

Duke Scholars

Published In

Biorheology

DOI

ISSN

0006-355X

Publication Date

1984

Volume

21

Issue

4

Start / End Page

539 / 558

Location

Netherlands

Related Subject Headings

  • Venules
  • Vasodilation
  • Thrombosis
  • Rats, Inbred F344
  • Rats
  • Microcirculation
  • Mammary Neoplasms, Experimental
  • Hot Temperature
  • Blood Flow Velocity
  • Biomedical Engineering
 

Citation

APA
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ICMJE
MLA
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Dewhirst, M., Gross, J. F., Sim, D., Arnold, P., & Boyer, D. (1984). The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. Biorheology, 21(4), 539–558. https://doi.org/10.3233/bir-1984-21413
Dewhirst, M., J. F. Gross, D. Sim, P. Arnold, and D. Boyer. “The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow.Biorheology 21, no. 4 (1984): 539–58. https://doi.org/10.3233/bir-1984-21413.
Dewhirst M, Gross JF, Sim D, Arnold P, Boyer D. The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. Biorheology. 1984;21(4):539–58.
Dewhirst, M., et al. “The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow.Biorheology, vol. 21, no. 4, 1984, pp. 539–58. Pubmed, doi:10.3233/bir-1984-21413.
Dewhirst M, Gross JF, Sim D, Arnold P, Boyer D. The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. Biorheology. 1984;21(4):539–558.

Published In

Biorheology

DOI

ISSN

0006-355X

Publication Date

1984

Volume

21

Issue

4

Start / End Page

539 / 558

Location

Netherlands

Related Subject Headings

  • Venules
  • Vasodilation
  • Thrombosis
  • Rats, Inbred F344
  • Rats
  • Microcirculation
  • Mammary Neoplasms, Experimental
  • Hot Temperature
  • Blood Flow Velocity
  • Biomedical Engineering