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Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone

Publication ,  Journal Article
Dewhirst, MW; Sim, DA; Parsells, JL; Wilson, S; DeYoung, D
Published in: Cancer Research
December 1, 1983

Most early-phase testing of new therapeutic modalities involves analysis of initial tumor response as opposed to estimation of long-term response. In this study, the validity of initial response rates to predict long-term responses was examined for tumors treated with radiotherapy alone compared with heat combined with radiotherapy. A total of 130 pet animals with either squamous cell carcinomas, melanomas, fibrosarcomas, mammary adenocarcinomas, or mast cell sarcomas were randomized to receive either radiation alone (XRT) or heat + radiation (Δ + XRT). Responses to treatment were evaluated by response rates and response duration. The complete response (CR) rates were consistently higher for Δ + XRT than for XRT across different histology groups. The combined therapy led to prolonged tumor response in all histological subgroups except melanomas, which had a longer response duration when treated with XRT alone (p = 0.043). This was in spite of a relatively high CR rate in that group (100% versus 12.5% for Δ + XRT and XRT, respectively). In contrast, while no significant improvement in CR rate was observed for dermal squamous cell carcinomas treated with Δ + XRT (XRT = 52.9% Δ + XRT = 68.8%), a significant improvement in response duration was noted (p = 0.002). These are two examples where CR rate did not predict long-term response. When all histological subgroups were combined (except melanomas), the CR rate was higher (p < 0.001), and response duration was prolonged (p = 0.031) for Δ + XRT compared to XRT alone. © 1983, American Association for Cancer Research. All rights reserved.

Duke Scholars

Published In

Cancer Research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

December 1, 1983

Volume

43

Issue

20

Start / End Page

5735 / 5741

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dewhirst, M. W., Sim, D. A., Parsells, J. L., Wilson, S., & DeYoung, D. (1983). Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone. Cancer Research, 43(20), 5735–5741.
Dewhirst, M. W., D. A. Sim, J. L. Parsells, S. Wilson, and D. DeYoung. “Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone.” Cancer Research 43, no. 20 (December 1, 1983): 5735–41.
Dewhirst MW, Sim DA, Parsells JL, Wilson S, DeYoung D. Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone. Cancer Research. 1983 Dec 1;43(20):5735–41.
Dewhirst, M. W., et al. “Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone.” Cancer Research, vol. 43, no. 20, Dec. 1983, pp. 5735–41.
Dewhirst MW, Sim DA, Parsells JL, Wilson S, DeYoung D. Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone. Cancer Research. 1983 Dec 1;43(20):5735–5741.

Published In

Cancer Research

EISSN

1538-7445

ISSN

0008-5472

Publication Date

December 1, 1983

Volume

43

Issue

20

Start / End Page

5735 / 5741

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1112 Oncology and Carcinogenesis