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Recent progress in angiotensin II type 2 receptor research in the cardiovascular system.

Publication ,  Journal Article
Horiuchi, M; Akishita, M; Dzau, VJ
Published in: Hypertension
February 1999

Angiotensin II (Ang II) plays an important role in regulating cardiovascular hemodynamics and structure. Multiple lines of evidence have suggested the existence of Ang II receptor subtypes, and at least 2 distinct receptor subtypes have been defined on the basis of their differential pharmacological and biochemical properties and designated as type 1 (AT1) and type 2 (AT2) receptors. To date, most of the known effects of Ang II in adult tissues are attributable to the AT1 receptor. Recent cloning of the AT2 receptor contributes to reveal its physiological functions, but many functions of the AT2 receptor are still an enigma. AT1 and AT2 receptors belong to the 7-transmembrane, G protein-coupled receptor family. However, accumulating evidence demonstrates that the function and signaling mechanisms of these receptor subtypes are quite different, and these receptors may exert opposite effects in terms of cell growth and blood pressure regulation. We will review the role of the AT2 receptor in the cardiovascular system and the molecular and cellular mechanisms of AT2 receptor action.

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Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

February 1999

Volume

33

Issue

2

Start / End Page

613 / 621

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Angiotensin
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Physiological Phenomena
  • Blood Pressure
  • Animals
  • Angiotensin II
  • Adult
  • 3202 Clinical sciences
 

Citation

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Horiuchi, M., Akishita, M., & Dzau, V. J. (1999). Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension, 33(2), 613–621. https://doi.org/10.1161/01.hyp.33.2.613
Horiuchi, M., M. Akishita, and V. J. Dzau. “Recent progress in angiotensin II type 2 receptor research in the cardiovascular system.Hypertension 33, no. 2 (February 1999): 613–21. https://doi.org/10.1161/01.hyp.33.2.613.
Horiuchi M, Akishita M, Dzau VJ. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension. 1999 Feb;33(2):613–21.
Horiuchi, M., et al. “Recent progress in angiotensin II type 2 receptor research in the cardiovascular system.Hypertension, vol. 33, no. 2, Feb. 1999, pp. 613–21. Pubmed, doi:10.1161/01.hyp.33.2.613.
Horiuchi M, Akishita M, Dzau VJ. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension. 1999 Feb;33(2):613–621.

Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

February 1999

Volume

33

Issue

2

Start / End Page

613 / 621

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Angiotensin
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Physiological Phenomena
  • Blood Pressure
  • Animals
  • Angiotensin II
  • Adult
  • 3202 Clinical sciences