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[Experimental approaches for gene therapy modification of vascular remodeling].

Publication ,  Journal Article
von der Leyen, HE; Dzau, VJ
Published in: Z Kardiol
October 1995

The active process of vascular remodeling involves changes in several cellular processes like cell growth, cell death, cell migration, and extracellular matrix production or degradation. The recent development of in vivo gene transfer technology has created a powerful new tool for the study of vascular remodeling by providing methods to overexpress or to inhibit specific local factors which are believed to contribute to the process of structural changes within the vasculature. The following overview describes recently published studies which investigated the effects of gene overexpression or inhibition on the process of vascular remodeling. The technology of gene transfer provides the opportunity for the development of novel therapeutic strategies such as gene replacement, gene correction, or gene augmentation, thus paving the way for gene therapy as treatment for vascular disease.

Duke Scholars

Published In

Z Kardiol

ISSN

0300-5860

Publication Date

October 1995

Volume

84

Issue

10

Start / End Page

791 / 797

Location

Germany

Related Subject Headings

  • Tunica Intima
  • Muscle, Smooth, Vascular
  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Gene Expression
  • Extracellular Matrix Proteins
  • Cell Movement
  • Cell Division
  • Cardiovascular System & Hematology
 

Citation

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ICMJE
MLA
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von der Leyen, H. E., & Dzau, V. J. (1995). [Experimental approaches for gene therapy modification of vascular remodeling]. Z Kardiol, 84(10), 791–797.
Leyen, H. E. von der, and V. J. Dzau. “[Experimental approaches for gene therapy modification of vascular remodeling].Z Kardiol 84, no. 10 (October 1995): 791–97.
von der Leyen HE, Dzau VJ. [Experimental approaches for gene therapy modification of vascular remodeling]. Z Kardiol. 1995 Oct;84(10):791–7.
von der Leyen, H. E., and V. J. Dzau. “[Experimental approaches for gene therapy modification of vascular remodeling].Z Kardiol, vol. 84, no. 10, Oct. 1995, pp. 791–97.
von der Leyen HE, Dzau VJ. [Experimental approaches for gene therapy modification of vascular remodeling]. Z Kardiol. 1995 Oct;84(10):791–797.

Published In

Z Kardiol

ISSN

0300-5860

Publication Date

October 1995

Volume

84

Issue

10

Start / End Page

791 / 797

Location

Germany

Related Subject Headings

  • Tunica Intima
  • Muscle, Smooth, Vascular
  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Gene Expression
  • Extracellular Matrix Proteins
  • Cell Movement
  • Cell Division
  • Cardiovascular System & Hematology