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A genetic linkage map of the laboratory rat, Rattus norvegicus.

Publication ,  Journal Article
Jacob, HJ; Brown, DM; Bunker, RK; Daly, MJ; Dzau, VJ; Goodman, A; Koike, G; Kren, V; Kurtz, T; Lernmark, A
Published in: Nat Genet
January 1995

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR x BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

January 1995

Volume

9

Issue

1

Start / End Page

63 / 69

Location

United States

Related Subject Headings

  • Repetitive Sequences, Nucleic Acid
  • Rats, Inbred SHR
  • Rats, Inbred BN
  • Rats
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Male
  • Genome
  • Genetic Markers
 

Citation

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Jacob, H. J., Brown, D. M., Bunker, R. K., Daly, M. J., Dzau, V. J., Goodman, A., … Lernmark, A. (1995). A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet, 9(1), 63–69. https://doi.org/10.1038/ng0195-63
Jacob, H. J., D. M. Brown, R. K. Bunker, M. J. Daly, V. J. Dzau, A. Goodman, G. Koike, V. Kren, T. Kurtz, and A. Lernmark. “A genetic linkage map of the laboratory rat, Rattus norvegicus.Nat Genet 9, no. 1 (January 1995): 63–69. https://doi.org/10.1038/ng0195-63.
Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, et al. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet. 1995 Jan;9(1):63–9.
Jacob, H. J., et al. “A genetic linkage map of the laboratory rat, Rattus norvegicus.Nat Genet, vol. 9, no. 1, Jan. 1995, pp. 63–69. Pubmed, doi:10.1038/ng0195-63.
Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark A. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet. 1995 Jan;9(1):63–69.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

January 1995

Volume

9

Issue

1

Start / End Page

63 / 69

Location

United States

Related Subject Headings

  • Repetitive Sequences, Nucleic Acid
  • Rats, Inbred SHR
  • Rats, Inbred BN
  • Rats
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • Male
  • Genome
  • Genetic Markers