Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody.
Publication
, Journal Article
Dzau, VJ; Brenner, A; Emmett, N; Haber, E
Published in: Clin Sci (Lond)
December 1980
1. The major angiotensin I-generating activity of rat brain extracts has a pH optimum different from that of renal renin and is not inhibited by renin specific antibody. 2. Affinity chromatography utilizing renin specific antibody, pepstatin and alpha-casein yielded fractions that resembled renal renin more closely with respect to antibody inhibition and pH optimum as well as an absence of the ability to hydrolyse haemoglobin. 3. We conclude that rat brain contains a host of enzymes with angiotensin I-generating activity including acid and neutral proteases and an enzyme with the immunochemical identity of renal renin. The biosynthetic origins of this renin-like protein remain uncertain.
Duke Scholars
Published In
Clin Sci (Lond)
DOI
ISSN
0143-5221
Publication Date
December 1980
Volume
59 Suppl 6
Start / End Page
45s / 47s
Location
England
Related Subject Headings
- Renin
- Rats
- Male
- Hydrogen-Ion Concentration
- Female
- Chromatography, Affinity
- Cardiovascular System & Hematology
- Brain
- Antigen-Antibody Reactions
- Antibody Specificity
Citation
APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J., Brenner, A., Emmett, N., & Haber, E. (1980). Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody. Clin Sci (Lond), 59 Suppl 6, 45s-47s. https://doi.org/10.1042/cs059045s
Dzau, V. J., A. Brenner, N. Emmett, and E. Haber. “Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody.” Clin Sci (Lond) 59 Suppl 6 (December 1980): 45s-47s. https://doi.org/10.1042/cs059045s.
Dzau VJ, Brenner A, Emmett N, Haber E. Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody. Clin Sci (Lond). 1980 Dec;59 Suppl 6:45s-47s.
Dzau, V. J., et al. “Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody.” Clin Sci (Lond), vol. 59 Suppl 6, Dec. 1980, pp. 45s-47s. Pubmed, doi:10.1042/cs059045s.
Dzau VJ, Brenner A, Emmett N, Haber E. Identification of renin and renin-like enzymes in rat brain by a renin-specific antibody. Clin Sci (Lond). 1980 Dec;59 Suppl 6:45s-47s.
Published In
Clin Sci (Lond)
DOI
ISSN
0143-5221
Publication Date
December 1980
Volume
59 Suppl 6
Start / End Page
45s / 47s
Location
England
Related Subject Headings
- Renin
- Rats
- Male
- Hydrogen-Ion Concentration
- Female
- Chromatography, Affinity
- Cardiovascular System & Hematology
- Brain
- Antigen-Antibody Reactions
- Antibody Specificity