Skip to main content
Journal cover image

Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention.

Publication ,  Journal Article
Sinnaeve, PR; Simes, J; Yusuf, S; Garg, J; Mehta, S; Eikelboom, J; Bittl, JA; Serruys, P; Topol, EJ; Granger, CB
Published in: Eur Heart J
November 2005

AIMS: We evaluated the effect of direct thrombin inhibitors (DTIs) in patients undergoing early percutaneous coronary intervention (PCI), using the DTI Trialists' Collaboration database of 35,970 patients from 11 randomized trials of DTIs vs. heparin. METHODS AND RESULTS: We performed a Cox proportional hazards regression analysis with PCI as a time-dependent covariate to assess the independent impact of DTIs according to the performance of early PCI. PCI was performed in 7049 patients in the first 72 h after randomization. In trials in which PCI was not planned, DTIs were associated with a 10% relative risk reduction in death or myocardial infarction at 30 days (HR=0.90, 95% CI: 0.84-0.97). This benefit was found to be greater in patients undergoing early PCI (HR=0.66, 95% CI: 0.48-0.91) than those undergoing non-early PCI (HR=0.94, 95% CI: 0.86-1.03). After adjustment for baseline characteristics and propensity to undergo PCI, the risk of death or myocardial infarction remained lower with DTI (HR=0.62, 95% CI: 0.44-0.89). CONCLUSION: After adjustment for baseline differences and propensity to undergo early PCI, DTIs appeared to be more effective than heparin in reducing death or re-infarction among patients undergoing early PCI.

Duke Scholars

Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

November 2005

Volume

26

Issue

22

Start / End Page

2396 / 2403

Location

England

Related Subject Headings

  • Treatment Outcome
  • Thrombin
  • Syndrome
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Male
  • Humans
  • Heparin
  • Female
  • Coronary Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sinnaeve, P. R., Simes, J., Yusuf, S., Garg, J., Mehta, S., Eikelboom, J., … Granger, C. B. (2005). Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention. Eur Heart J, 26(22), 2396–2403. https://doi.org/10.1093/eurheartj/ehi590
Sinnaeve, Peter R., John Simes, Salim Yusuf, Jyotsna Garg, Shamir Mehta, John Eikelboom, John A. Bittl, Patrick Serruys, Eric J. Topol, and Christopher B. Granger. “Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention.Eur Heart J 26, no. 22 (November 2005): 2396–2403. https://doi.org/10.1093/eurheartj/ehi590.
Sinnaeve PR, Simes J, Yusuf S, Garg J, Mehta S, Eikelboom J, et al. Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention. Eur Heart J. 2005 Nov;26(22):2396–403.
Sinnaeve, Peter R., et al. “Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention.Eur Heart J, vol. 26, no. 22, Nov. 2005, pp. 2396–403. Pubmed, doi:10.1093/eurheartj/ehi590.
Sinnaeve PR, Simes J, Yusuf S, Garg J, Mehta S, Eikelboom J, Bittl JA, Serruys P, Topol EJ, Granger CB. Direct thrombin inhibitors in acute coronary syndromes: effect in patients undergoing early percutaneous coronary intervention. Eur Heart J. 2005 Nov;26(22):2396–2403.
Journal cover image

Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

November 2005

Volume

26

Issue

22

Start / End Page

2396 / 2403

Location

England

Related Subject Headings

  • Treatment Outcome
  • Thrombin
  • Syndrome
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Male
  • Humans
  • Heparin
  • Female
  • Coronary Disease