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Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study.

Publication ,  Journal Article
Peters, ME; Rosenberg, PB; Steinberg, M; Norton, MC; Welsh-Bohmer, KA; Hayden, KM; Breitner, J; Tschanz, JT; Lyketsos, CG ...
Published in: Am J Geriatr Psychiatry
September 12, 2012

OBJECTIVES:: To examine the association of neuropsychiatric symptom (NPS) severity with risk of transition to all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD). DESIGN:: Survival analysis of time to dementia, AD, or VaD onset. SETTING:: Population-based study. PARTICIPANTS:: 230 participants diagnosed with cognitive impairment, no dementia (CIND) from the Cache County Study of Memory Health and Aging were followed for a mean of 3.3 years. MEASUREMENTS:: The Neuropsychiatric Inventory (NPI) was used to quantify the presence, frequency, and severity of NPS. Chi-squared statistics, t-tests, and Cox proportional hazard ratios were used to assess associations. RESULTS:: The conversion rate from CIND to all-cause dementia was 12% per year, with risk factors including an APOE [Latin Small Letter Open E]4 allele, lower Mini-Mental State Examination, lower 3MS, and higher CDR sum-of-boxes. The presence of at least one NPS was a risk factor for all-cause dementia, as was the presence of NPS with mild severity. Nighttime behaviors were a risk factor for all-cause dementia and of AD, whereas hallucinations were a risk factor for VaD. CONCLUSIONS:: These data confirm that NPS are risk factors for conversion from CIND to dementia. Of special interest is that even NPS of mild severity are a risk for all-cause dementia or AD.

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Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

September 12, 2012

Related Subject Headings

  • Geriatrics
  • 5203 Clinical and health psychology
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

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Peters, M. E., Rosenberg, P. B., Steinberg, M., Norton, M. C., Welsh-Bohmer, K. A., Hayden, K. M., … the Cache County Investigators, . (2012). Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study. Am J Geriatr Psychiatry. https://doi.org/10.1097/JGP.0b013e318267014b
Peters, M. E., P. B. Rosenberg, M. Steinberg, M. C. Norton, K. A. Welsh-Bohmer, K. M. Hayden, J. Breitner, J. T. Tschanz, C. G. Lyketsos, and C. G. the Cache County Investigators. “Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study.Am J Geriatr Psychiatry, September 12, 2012. https://doi.org/10.1097/JGP.0b013e318267014b.
Peters ME, Rosenberg PB, Steinberg M, Norton MC, Welsh-Bohmer KA, Hayden KM, et al. Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study. Am J Geriatr Psychiatry. 2012 Sep 12;
Peters, M. E., et al. “Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study.Am J Geriatr Psychiatry, Sept. 2012. Pubmed, doi:10.1097/JGP.0b013e318267014b.
Peters ME, Rosenberg PB, Steinberg M, Norton MC, Welsh-Bohmer KA, Hayden KM, Breitner J, Tschanz JT, Lyketsos CG, the Cache County Investigators. Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study. Am J Geriatr Psychiatry. 2012 Sep 12;
Journal cover image

Published In

Am J Geriatr Psychiatry

DOI

EISSN

1545-7214

Publication Date

September 12, 2012

Related Subject Headings

  • Geriatrics
  • 5203 Clinical and health psychology
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences